Native Human BCHE


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Native Human BCHE

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Cat.No. : BCHE-26067TH
Product Overview : Full length native Human Butyrylcholinesterase from Human plasma/serum. Amino acids 29-602, Predicted MWt 68kDa.
Description : Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.
Protein length : 574 amino acids
Molecular Weight : 65.000kDa
Tissue specificity : Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
Biological activity : Butyrylcholinesterase enzyme assay: One unit of Butyrylcholinesterase will hydrolyse 1.0μ mole of Butyrylcholine per min at pH 8.0 at 37°C.
Form : Lyophilised:Use of a phosphate buffer pH >7.0 containing 0.15M NaCl is recommended.
Storage buffer : Preservative: NoneConstituents: 0.02M Ammonium bicarbonate. May contain traces of buffer salts.
Storage : Store at +4°C.
Sequence Similarities : Belongs to the type-B carboxylesterase/lipase family.
Gene Name : BCHE butyrylcholinesterase [ Homo sapiens ]
Official Symbol : BCHE
Synonyms : BCHE; butyrylcholinesterase; CHE1, cholinesterase 1; cholinesterase; E1;
Gene ID : 590
mRNA Refseq : NM_000055
Protein Refseq : NP_000046
Uniprot ID : P06276
Chromosome Location : 3q26.1-q26.2
Pathway : Diabetes pathways, organism-specific biosystem; Irinotecan Pathway, organism-specific biosystem; Synthesis, Secretion, and Deacylation of Ghrelin, organism-specific biosystem;
Function : acetylcholinesterase activity; acetylcholinesterase activity; acetylcholinesterase activity; beta-amyloid binding; carboxylesterase activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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