Recombinant Human CAMK2D

• Cat.No.: CAMK2D-27263TH
• Product Overview: Recombinant full length Human CaMKII delta with an N terminal proprietary tag, expressed by Baculovirus in Sf9 cells, MWt 77 kDa.

Specification

• Description: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.
• Tissue specificity: Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle.
• Biological activity: The specific activity of CAMK2D-27263TH was determined to be 5860 nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: CAMK2D calcium/calmodulin-dependent protein kinase II delta [ Homo sapiens ]
• Official Symbol: CAMK2D
• Synonyms: CAMK2D; calcium/calmodulin-dependent protein kinase II delta; calcium/calmodulin dependent protein kinase (CaM kinase) II delta , CAMKD; calcium/calmodulin-dependent protein kinase type II subunit delta
• Gene ID: 817
• mRNA Refseq: NM_001221
• Protein Refseq: NP_001212
• MIM: 607708
• Uniprot ID: Q13557
• Chromosome Location: 4q26
• Pathway: Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; CREB phosphorylation through the activation of CaMKII, organism-specific biosystem; CREB phosphorylation through the activation of Ras, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem
• Function: ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; nucleotide binding