Recombinant Human CBR3, His-tagged

• Cat.No.: CBR3-26328TH
• Product Overview: Recombinant full length Human CBR3 (amino acids 1-277) with N terminal His tag; 297 aa, 33kDa.

Specification

• Description: Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols.The enzyme is classified as a monomeric NADPH-dependent oxidoreductase.CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.
• Protein length: 277 amino acids
• Conjugation: HIS
• Molecular Weight: 33.000kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:10% Glycerol, 0.32% Tris HCl
• Storage: Please see Notes section
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS ETLTEGDLVD LMKKFVEDTK NEVHEREGWP NSPYGVSKLG VTVLSRILAR RLDEKRKADR ILVNACCPGP VKTDMDGKDS IRTVEEGAET PVYLALLPPD ATEPQGQLVH DKVVQNW
• Sequence Similarities: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Gene Information

• Gene Name: CBR3 carbonyl reductase 3 [ Homo sapiens ]
• Official Symbol: CBR3
• Synonyms: CBR3; carbonyl reductase 3; carbonyl reductase [NADPH] 3; SDR21C2; short chain dehydrogenase/reductase family 21C; member 2
• Gene ID: 874
• mRNA Refseq: NM_001236
• Protein Refseq: NP_001227
• MIM: 603608
• Uniprot ID: O75828
• Chromosome Location: 21q22.2
• Pathway: Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P450, conserved biosystem
• Function: 3-keto sterol reductase activity; NADPH binding; carbonyl reductase (NADPH) activity; nucleotide binding; oxidoreductase activity