Recombinant Human CHEK1, His-tagged CHEK1-26714TH

Recombinant Human CHEK1, His-tagged


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Recombinant Human CHEK1, His-tagged

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Cat.No. : CHEK1-26714TH
Product Overview : Recombinant full length human Chk1 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag, 59kDa.
Description : The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
Conjugation : HIS
Biological activity : Specific activity: 144 nmol /min/mgas determined by Kinase assay.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name : CHEK1 checkpoint kinase 1 [ Homo sapiens ]
Official Symbol : CHEK1
Synonyms : CHEK1; checkpoint kinase 1; CHK1 (checkpoint, S.pombe) homolog; serine/threonine-protein kinase Chk1; CHK1;
Gene ID : 1111
mRNA Refseq : NM_001114121
Protein Refseq : NP_001107593
MIM : 603078
Uniprot ID : O14757
Chromosome Location : 11q24.2
Pathway : Activation of ATR in response to replication stress, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem;
Function : ATP binding; histone kinase activity (H3-T11 specific); nucleotide binding; protein binding; protein serine/threonine kinase activity;

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