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Official Full Name checkpoint kinase 1
Background The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Synonyms CHEK1; checkpoint kinase 1; CHK1; serine/threonine-protein kinase Chk1; Chk1-S; checkpoint kinase-1; CHK1 checkpoint homolog; cell cycle checkpoint kinase; Checkpoint, S. pombe, homolog of, 1;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CHEK1-1125H CHK1 Checkpoint Homolog (S. pombe) Sf9 Insect Cell N/A
    Human CHEK1-1132H Recombinant Human CHK1 Checkpoint Homolog (S. Pombe) , GST-tagged Sf9 Insect Cell GST
    Human CHEK1-1220H Recombinant Human CHEK1 Protein, GST-His-Tagged Insect Cell GST/His
    Human CHEK1-1221H Recombinant Human CHEK1 Protein, GST-Tagged Wheat Germ GST
    Human CHEK1-229H Recombinant Human CHEK1 Protein, GST-tagged Insect Cell GST
    Human CHEK1-26453TH Recombinant Human CHEK1 N/A
    Human CHEK1-26454TH Recombinant Human CHEK1 E.coli N/A
    Human CHEK1-26714TH Recombinant Human CHEK1, His-tagged His
    Human CHEK1-281H Recombinant Human CHEK1, His-tagged, Active Sf9 Insect Cell GST
    Human CHEK1-3217H Recombinant Human CHEK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CHEK1-39H Recombinant Human CHEK1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human CHEK1-438HCL Recombinant Human CHEK1 cell lysate Insect Cell N/A
    Human CHEK1-4838H Recombinant Human CHK1 Checkpoint Homolog (S. pombe), GST-tagged Sf9 Insect Cell GST
    Human CHEK1-629H Recombinant Human CHEK1 Mammalian Cell His
    Mouse CHEK1-001MCL Recombinant Mouse CHEK1 cell lysate Insect Cell N/A
    Mouse Chek1-1833M Recombinant Mouse Chek1 protein, His & T7-tagged E.coli His/T7
    Mouse Chek1-8670M Recombinant Mouse Chek1, His & GST tagged Insect Cell His/GST
    Mouse Chek1-884M Recombinant Mouse Chek1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CHEK1-1368R Recombinant Rat CHEK1 Protein Mammalian Cell His
    Zebrafish CHEK1-10539Z Recombinant Zebrafish CHEK1 Mammalian Cell His

    CHEK1 involved in several pathways and played different roles in them. We selected most pathways CHEK1 participated on our site, such as Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHEK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of ATR in response to replication stress RAD9B; CLSPN; RAD1; MCM10; DBF4; CDK2; MCM8; RAD9A; CHEK1; RAD9
    Cell Cycle YWHAE2; SKA1; CEP78; MAD1L1; SET; CUL1; CP110; FOXM1; YWHAZ; YWHAQB
    Cell Cycle Checkpoints BRE; CDK2; HTATIP; THRSP; UBE2V2; MCM8; CDKN1B; HIST3H2BB; YWHAQ; HUS1
    Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex CHEK1
    Circadian rhythm pathway NONO; CHEK1; DEC1; TIMELESS
    DNA Double-Strand Break Repair PPP4R2B; PPP4CB; GEN1; WRN; RBBP8; PPP4R2A; TIPIN; EME1; KDM4B; DNA2

    CHEK1 has several biochemical functions, for example, ATP binding, histone kinase activity (H3-T11 specific), protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHEK1 itself. We selected most functions CHEK1 had, and list some proteins which have the same functions with CHEK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PANK2; HK3; DNAH11; NOL9; ABCG2D; VRK2; SCYL3; NEK8; CAMK1G; DDR2
    histone kinase activity (H3-T11 specific) CHEK1; PKN1
    protein binding UBR4; NR2C1; BMF; HIP1; PIN1; STK38L; PUM2; GZMB; FRMPD2; RPL4
    protein kinase activity PRKG2; DCLK2; GUCY2C; MAP3K10; TNIKB; STK25; CSNK1D; KSR1; MAP3K3; ROCK1
    protein serine/threonine kinase activity MARK2; MAP3K12; BUB1B; AKT3; TSSK2; CAMKK1A; BMPR1AA; TESK2; PRKCHA; STK35L

    CHEK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHEK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHEK1.


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