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Recombinant Human COMP, FLAG-tagged

Cat.No. : COMP-26251TH
Product Overview : Recombinant Full length Human COMP with an N terminal DDDDK tag; 750aa, 82.4kDa.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
Protein length : 737 amino acids
Conjugation : FLAG
Molecular Weight : 82.400kDa inclusive of tags
Source : HEK 293 cells
Tissue specificity : Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.
Form : Lyophilised:Add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely.
Purity : by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 50mM Sodium chloride, 20mM Tris, pH 7.5
Storage : Store at -80°C
Sequences of amino acids : HVDYKDDDDKPAGQGQSPLGSDLGP QMLRELQETNAALQDVRELLRQQVR EITFLKNTVMECDACGMQQSVRTGL PSVRPLLHCAPGFCFPGVACIQTES GARCGPCPAGFTGNGSHCTDVNECN AHPCFPRVRCINTSPGFRCEACPPG YSGPTHQGVGLAFAKANKQVCTDIN ECETGQHNCVPNSVCINTRGSFQCG PCQPGFVGDQASGCQRRAQRFCPDG SPSECHEHADCVLERDGSRSCVCAV GWAGNGILCGRDTDLDGFPDEKLRC PERQCRKDNCVTVPNSGQEDVDRDG IGDACDPDADGDGVPNEKDNCPLVR NPDQRNTDEDKWGDACDNCRSQKND DQKDTDQDGRGDACDDDIDGDRIRN QADNCPRVPNSDQKDSDGDGIGDAC DNCPQKSNPDQADVDHDFVGDACDS DQDQDGDGHQDSRDNCPTVPNSAQE DSDHDGQGDACDDDDDNDGVPDSRD NCRLVPNPGQEDADRDGVGDVCQDD FDADKVVDKIDVCPENAEVTLTDFR AFQTVVLDPEGDAQIDPNWVVLNQG REIVQTMNSDPGLAVGYTAFNGVDF EGTFHVNTVTDDDYAGFIFGYQDSS SFYVVMWKQMEQTYWQANPFRAVAE PGIQLKAVKSSTGPGEQLRNALWHT GDTESQVRLLWKDPRNVGWKDKKSY RWFLQHRPQVGYIRVRFYEGPELVA DSNVVLDTTMRGGRLGVFCFSQENI IWANLRYRCNDTIPEDYETHQLRQA
Sequence Similarities : Belongs to the thrombospondin family.Contains 4 EGF-like domains.Contains 1 TSP C-terminal (TSPC) domain.Contains 8 TSP type-3 repeats.
Gene Name : COMP cartilage oligomeric matrix protein [ Homo sapiens ]
Official Symbol : COMP
Synonyms : COMP; cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , EDM1, EPD1, PSACH; MED; THBS5; thrombospondin 5;
Gene ID : 1311
mRNA Refseq : NM_000095
Protein Refseq : NP_000086
MIM : 600310
Uniprot ID : P49747
Chromosome Location : 19p13.1
Pathway : ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem;
Function : calcium ion binding; collagen binding; extracellular matrix structural constituent; heparan sulfate proteoglycan binding; heparin binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How are COMP protein levels measured in clinical settings? 11/02/2021

COMP levels are typically assessed through blood tests or synovial fluid analysis.

Are there limitations in using COMP levels as a standalone diagnostic tool? 11/24/2020

Yes, while COMP levels are indicative of joint diseases, they are often used alongside other diagnostic tools for a comprehensive assessment.

Can COMP levels be used to monitor treatment effectiveness? 10/14/2020

Monitoring changes in COMP levels can be valuable in assessing the effectiveness of treatments targeting joint diseases.

Can COMP protein be a potential target for future drug development? 11/26/2017

Given its involvement in joint diseases, COMP might be a target for drug development, but this area requires further exploration.

Can COMP levels predict disease progression in arthritis? 06/13/2017

Elevated COMP levels often correlate with more rapid disease progression in arthritis, aiding in prognosis.

Customer Reviews (3)

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Reviews
03/26/2021

    One of the standout factors that distinguishes the COMP protein is the manufacturer's unwavering commitment to exceptional technical support.

    01/15/2021

      Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the COMP protein is an invaluable tool for researchers.

      06/15/2017

        The COMP protein offers exceptional quality that meets the rigorous demands of experimental research.

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