Recombinant Human DDIT4

• Cat.No.: DDIT4-28311TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-232 of Human DDIT4

Specification

• Description: DDIT4, also known as Dig2 or REDD1, is thought to have function in the regulation of reactive oxygen species. In response to stress due to DNA damage and glucocorticoid treatment, DDIT4 is upregulated at the transcriptional level.
• Source: E. coli
• Tissue specificity: Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level).
• Form: Liquid
• Purity: Purified via His tag
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the DDIT4 family.

Gene Information

• Gene Name: DDIT4 DNA-damage-inducible transcript 4 [ Homo sapiens ]
• Official Symbol: DDIT4
• Synonyms: DDIT4; DNA-damage-inducible transcript 4; DNA damage-inducible transcript 4 protein; Dig2; FLJ20500; HIF 1 responsive RTP801; REDD 1; REDD1; RTP801
• Gene ID: 54541
• mRNA Refseq: NM_019058
• Protein Refseq: NP_061931
• MIM: 607729
• Uniprot ID: Q9NX09
• Chromosome Location: 10q22.1
• Pathway: Direct p53 effectors, organism-specific biosystem; mTOR signaling pathway, organism-specific biosystem; mTOR signaling pathway, organism-specific biosystem; mTOR signaling pathway, conserved biosystem
• Function: 14-3-3 protein binding