Recombinant Human ERN1

• Cat.No.: ERN1-28271TH
• Product Overview: Recombinant fragment of Human IRE1 with proprietary tag at the N terminal; Predicted MW 36.63 kDa, inclusive of tag.

Specification

• Description: The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Ubiquitously expressed. High levels observed in pancreatic tissue.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: EEVINLVDQTSENAPTTVSRDVEEK PAHAPARPEAPVDSMLKDMATIILS TFLLIGWVAFIITYPLSMHQQQQLQ HQQFQKELEKIQLLQQQQQQLPFHP
• Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Contains 1 KEN domain.Contains 1 protein kinase domain.

Gene Information

• Gene Name: ERN1 endoplasmic reticulum to nucleus signaling 1 [ Homo sapiens ]
• Official Symbol: ERN1
• Synonyms: ERN1; endoplasmic reticulum to nucleus signaling 1; ER to nucleus signalling 1; serine/threonine-protein kinase/endoribonuclease IRE1; inositol requiring enzyme 1; IRE1; IRE1P
• Gene ID: 2081
• mRNA Refseq: NM_001433
• Protein Refseq: NP_001424
• MIM: 604033
• Uniprot ID: O75460
• Chromosome Location: 17q23
• Pathway: Activation of Chaperones by IRE1alpha, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Diabetes pathways, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem
• Function: ATP binding; endoribonuclease activity; endoribonuclease activity; endoribonuclease activity, producing 5-phosphomonoesters; hydrolase activity