Recombinant Human ERN1
Cat.No. : | ERN1-28271TH |
Product Overview : | Recombinant fragment of Human IRE1 with proprietary tag at the N terminal; Predicted MW 36.63 kDa, inclusive of tag. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. |
Protein length : | 100 amino acids |
Molecular Weight : | 36.630kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Ubiquitously expressed. High levels observed in pancreatic tissue. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | EEVINLVDQTSENAPTTVSRDVEEK PAHAPARPEAPVDSMLKDMATIILS TFLLIGWVAFIITYPLSMHQQQQLQ HQQFQKELEKIQLLQQQQQQLPFHP |
Sequence Similarities : | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Contains 1 KEN domain.Contains 1 protein kinase domain. |
Gene Name : | ERN1 endoplasmic reticulum to nucleus signaling 1 [ Homo sapiens ] |
Official Symbol : | ERN1 |
Synonyms : | ERN1; endoplasmic reticulum to nucleus signaling 1; ER to nucleus signalling 1; serine/threonine-protein kinase/endoribonuclease IRE1; inositol requiring enzyme 1; IRE1; IRE1P; |
Gene ID : | 2081 |
mRNA Refseq : | NM_001433 |
Protein Refseq : | NP_001424 |
MIM : | 604033 |
Uniprot ID : | O75460 |
Chromosome Location : | 17q23 |
Pathway : | Activation of Chaperones by IRE1alpha, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Diabetes pathways, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; |
Function : | ATP binding; endoribonuclease activity; endoribonuclease activity; endoribonuclease activity, producing 5-phosphomonoesters; hydrolase activity; |
Products Types
◆ Recombinant Protein | ||
ERN1-865H | Recombinant Human ERN1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ERN1-1490H | Recombinant Human ERN1 Protein, His-tagged | +Inquiry |
ERN1-3483H | Recombinant Human ERN1 Protein, GST-tagged | +Inquiry |
ERN1-590HCL | Recombinant Human ERN1 Overexpression Lysate(Pro 465-Leu 977) | +Inquiry |
ERN1-1110H | Recombinant Human ERN1 Protein (S24-V390), Tag Free | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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