Native Human F10

• Cat.No.: F10-26946TH
• Product Overview: Full length protein, corresponding to amino acids 41-488 of Human Factor Xa; 448 amino acids, 46kDa.

Specification

• Description: This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
• Tissue specificity: Plasma; synthesized in the liver.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20mM HEPES, 150mM Sodium chloride, pH 7.4
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the peptidase S1 family.Contains 2 EGF-like domains.Contains 1 Gla (gamma-carboxy-glutamate) domain.Contains 1 peptidase S1 domain.

Gene Information

• Gene Name: F10 coagulation factor X [ Homo sapiens ]
• Official Symbol: F10
• Synonyms: F10; coagulation factor X
• Gene ID: 2159
• mRNA Refseq: NM_000504
• Protein Refseq: NP_000495
• MIM: 613872
• Uniprot ID: P00742
• Chromosome Location: 13q34
• Pathway: Blood Clotting Cascade, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem
• Function: calcium ion binding; peptidase activity; phospholipid binding; protein binding; serine-type endopeptidase activity