Native Human F13A1

PRODUCTS

Home / Products / Native Human F13A1

Native Human F13A1

F13A1 Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat.No. : F13A1-28806TH
Product Overview : Full length native Factor XIIIa protein (purified) (Human).
Description : This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
Form : Liquid
Purity : Immunogen affinity purified
Storage buffer : Preservative: NoneConstituents: 50% Glycerol, 0.5mM EDTA
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the transglutaminase superfamily. Transglutaminase family.
Gene Name : F13A1 coagulation factor XIII, A1 polypeptide [ Homo sapiens ]
Official Symbol : F13A1
Synonyms : F13A1; coagulation factor XIII, A1 polypeptide; F13A; coagulation factor XIII A chain;
Gene ID : 2162
mRNA Refseq : NM_000129
Protein Refseq : NP_000120
MIM : 134570
Uniprot ID : P00488
Chromosome Location : 6p24.2-p23
Pathway : Common Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function : metal ion binding; protein-glutamine gamma-glutamyltransferase activity; protein-glutamine gamma-glutamyltransferase activity; transferase activity, transferring acyl groups;

Online Inquiry


  •  
  • Note: There will be extra charge for optional service!
  • Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2020 Creative BioMart. All Rights Reserved.