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Recombinant Human F13A1 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : F13A1-1890H
Product Overview : F13A1 MS Standard C13 and N15-labeled recombinant protein (NP_000120) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 83.3 kDa
AA Sequence : MSETSRTAFGGRRAVPPNNSNAAED DLPTVELQGVVPRGVNLQEFLNVTS VHLFKERWDTNKVDHHTDKYENNKL IVRRGQSFYVQIDFSRPYDPRRDLF RVEYVIGRYPQENKGTYIPVPIVSE LQSGKWGAKIVMREDRSVRLSIQSS PKCIVGKFRMYVAVWTPYGVLRTSR NPETDTYILFNPWCEDDAVYLDNEK EREEYVLNDIGVIFYGEVNDIKTRS WSYGQFEDGILDTCLYVMDRAQMDL SGRGNPIKVSRVGSAMVNAKDDEGV LVGSWDNIYAYGVPPSAWTGSVDIL LEYRSSENPVRYGQCWVFAGVFNTF LRCLGIPARIVTNYFSAHDNDANLQ MDIFLEEDGNVNSKLTKDSVWNYHC WNEAWMTRPDLPVGFGGWQAVDSTP QENSDGMYRCGPASVQAIKHGHVCF QFDAPFVFAEVNSDLIYITAKKDGT HVVENVDATHIGKLIVTKQIGGDGM MDITDTYKFQEGQEEERLALETALM YGAKKPLNTEGVMKSRSNVDMDFEV ENAVLGKDFKLSITFRNNSHNRYTI TAYLSANITFYTGVPKAEFKKETFD VTLEPLSFKKEAVLIQAGEYMGQLL EQASLHFFVTARINETRDVLAKQKS TVLTIPEIIIKVRGTQVVGSDMTVI VEFTNPLKETLRNVWVHLDGPGVTR PMKKMFREIRPNSTVQWEEVCRPWV SGHRKLIASMSSDSLRHVYGELDVQ IQRRPSMTRTRPLEQKLISEEDLAA NDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : F13A1 coagulation factor XIII A chain [ Homo sapiens (human) ]
Official Symbol : F13A1
Synonyms : F13A1; coagulation factor XIII, A1 polypeptide; F13A; coagulation factor XIII A chain; TGase; factor XIIIa; fibrinoligase; FSF, A subunit; coagulation factor XIIIa; transglutaminase A chain; transglutaminase. plasma; fibrin stabilizing factor, A subunit; coagulation factor XIII, A polypeptide; protein-glutamine gamma-glutamyltransferase A chain; bA525O21.1 (coagulation factor XIII, A1 polypeptide);
Gene ID : 2162
mRNA Refseq : NM_000129
Protein Refseq : NP_000120
MIM : 134570
UniProt ID : P00488

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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