"FGF2" Related Products

Native Human FGF2

Cat.No.: FGF2-26551TH
Product Overview: Human FGF basic.
Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
Source: E. coli
Tissue specificity: Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
Form: Lyophilised:Please reconstitute this product in 500ul 5mM Tris, pH7.6.
Purity: >95% by SDS-PAGE
Storage buffer: 10mM Tris pH 8.5 + 100 mM NaCl
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: Human FGF-basic is a 17.2 kDa protein containing 154 amino acid residues:MAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAE ERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFF FERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Sequence Similarities: Belongs to the heparin-binding growth factors family.
Gene Name: FGF2 fibroblast growth factor 2 (basic) [ Homo sapiens ]
Official Symbol: FGF2
Synonyms: FGF2; fibroblast growth factor 2 (basic); FGFB; heparin-binding growth factor 2;
Gene ID: 2247
mRNA Refseq: NM_002006
Protein Refseq: NP_001997
MIM: 134920
Uniprot ID: P09038
Chromosome Location: 4q26
Pathway: Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Downstream signaling of activated FGFR, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem;
Function: chemoattractant activity; cytokine activity; fibroblast growth factor binding; fibroblast growth factor receptor binding; growth factor activity;

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