Recombinant Human MMP3, His-tagged

• Cat.No.: MMP3-28202TH
• Product Overview: Full length native protein of Human MMP3.

Specification

• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
• Conjugation: HIS
• Form: Liquid
• Storage buffer: The enzyme is supplied as a mixture of the zymogen and active enzyme in:Preservative: 0.01% Sodium AzideConstituents: 50% Glycerol, 0.025% Brij 35, 5mM Calcium chloride, 250mM Sodium chloride, 25mM Tris, pH 7.4
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the peptidase M10A family.Contains 4 hemopexin-like domains.

Gene Information

• Gene Name: MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) [ Homo sapiens ]
• Official Symbol: MMP3
• Synonyms: MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3 (stromelysin 1, progelatinase) , STMY, STMY1; stromelysin-1
• Gene ID: 4314
• mRNA Refseq: NM_002422
• Protein Refseq: NP_002413
• Uniprot ID: P08254
• Chromosome Location: 11q22.3
• Pathway: Matrix Metalloproteinases, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem; Transcriptional misregulation in cancers, organism-specific biosystem; Transcriptional misregulation in cancers, conserved biosystem
• Function: calcium ion binding; metalloendopeptidase activity; peptidase activity; protein complex binding; zinc ion binding