Recombinant Human MUSK

• Cat.No.: MUSK-30261TH
• Product Overview: Recombinant fragment from human MUSK, cytoplasmic domain, amino acids 519-end.Expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 63kDa.

Specification

• Description: This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.
• Biological activity: Specific activity is6.7 nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family.Contains 1 FZ (frizzled) domain.Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.

Gene Information

• Gene Name: MUSK muscle, skeletal, receptor tyrosine kinase [ Homo sapiens ]
• Official Symbol: MUSK
• Synonyms: MUSK; muscle, skeletal, receptor tyrosine kinase; muscle, skeletal receptor tyrosine-protein kinase
• Gene ID: 4593
• mRNA Refseq: NM_001166280
• Protein Refseq: NP_001159752
• MIM: 601296
• Uniprot ID: O15146
• Chromosome Location: 9q31.3-q32
• Function: ATP binding; PDZ domain binding; nucleotide binding; receptor activity; transmembrane receptor protein tyrosine kinase activity

Reviews

11/20/2022

The MUSK protein's high quality, stellar technical support, and compatibility with diverse experimental approaches make it an optimal choice for meeting my research needs.

09/01/2017

Its usage in these techniques is highly praised by scientists worldwide, attesting to its effectiveness and significance in advancing scientific knowledge and understanding.

01/25/2017

Its ability to consistently provide accurate and reliable results makes it an invaluable tool for quantifying and detecting specific targets in biological samples.

Q&As

How is MUSK protein targeted in the treatment of autoimmune myasthenia gravis?

In autoimmune myasthenia gravis, immunosuppressive therapies and acetylcholinesterase inhibitors are commonly used to manage symptoms, and some treatments specifically target the immune response against MUSK.

Can MUSK protein abnormalities be detected early in life?

Yes, genetic testing and other diagnostic measures can identify MUSK protein abnormalities early in life, enabling prompt intervention and management.

Are there diagnostic tests for MUSK-related disorders?

Yes, diagnostic tests such as genetic testing and antibody assays can be employed to identify MUSK-related disorders.

How does MUSK protein contribute to muscle regeneration?

MUSK protein plays a role in signaling pathways that contribute to muscle regeneration, making it an important factor in tissue repair.

Can MUSK protein be a target for gene therapy?

Yes, gene therapy approaches aimed at restoring normal MUSK function are being explored as potential treatments for MUSK-related disorders.