Recombinant Human NAT2

• Cat.No.: NAT2-29721TH
• Product Overview: Recombinant full length Human NAT2 with a N terminal proprietary tag; Predicted MWt 58.01 kDa.

Specification

• Description: This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2).
• Protein length: 290 amino acids
• Molecular Weight: 58.010kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MDIEAYFERIGYKNSRNKLDLETLTDILEHQIRAVPFENL NMHCGQAMELGLEAIFDHIVRRNRGGWCLQVNQLLYWALT TIGFQTTMLGGYFYIPPVNKYSTGMVHLLLQVTIDGRNYI VDAGSGSSSQMWQPLELISGKDQPQVPCIFCLTEERGIWY LDQIRREQYITNKEFLNSHLLPKKKHQKIYLFTLEPQTIE DFESMNTYLQTSPTSSFITTSFCSLQTPEGVYCLVGFILT YRKFNYKDNTDLVEFKTLTEEEVEEVLKNIFKISLGRNLV PKPGDGSLTI
• Sequence Similarities: Belongs to the arylamine N-acetyltransferase family.

Gene Information

• Gene Name: NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) [ Homo sapiens ]
• Official Symbol: NAT2
• Synonyms: NAT2; N-acetyltransferase 2 (arylamine N-acetyltransferase); AAC2; arylamine N-acetyltransferase 2
• Gene ID: 10
• mRNA Refseq: NM_000015
• Protein Refseq: NP_000006
• MIM: 612182
• Uniprot ID: P11245
• Chromosome Location: 8p22
• Pathway: Acetylation, organism-specific biosystem; Biological oxidations, organism-specific biosystem; Caffeine metabolism, organism-specific biosystem; Caffeine metabolism, conserved biosystem; Drug metabolism - other enzymes, organism-specific biosystem
• Function: acetyltransferase activity; arylamine N-acetyltransferase activity; transferase activity, transferring acyl groups