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Recombinant Human NGF

Cat.No.: NGF-29918TH
Product Overview: Recombinant full-length mature Human NGF, 1-119 aa.
Description: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this genes expression is associated with allergic rhinitis.
Protein length: 119 amino acids
Molecular Weight: 13.600kDa
Source: E. coli
Biological activity: The ED50 as determined by the ability to stimulate neurite growth in Chick E9 DRG cells is
Form: Lyophilised:Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. The solution can be diluted into other aqueous buffers and stored at –20°C for future use.
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: None
Storage: Lyophilized protein should be stored below -20°C. Upon reconstitution aliquot and store below -18°C to prevent freeze-thaw cycles.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Sequence Similarities: Belongs to the NGF-beta family.
Gene Name: NGF nerve growth factor (beta polypeptide) [ Homo sapiens ]
Official Symbol: NGF
Synonyms: NGF; nerve growth factor (beta polypeptide); NGFB; beta-nerve growth factor;
Gene ID: 4803
mRNA Refseq: NM_002506
Protein Refseq: NP_002497
MIM: 162030
Uniprot ID: P01138
Chromosome Location: 1p13.1
Pathway: ARMS-mediated activation, organism-specific biosystem; Activation of TRKA receptors, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Axonal growth stimulation, organism-specific biosystem;
Function: growth factor activity; nerve growth factor receptor binding; receptor signaling protein activity; signal transducer activity;

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