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Recombinant Human PDK2, His-tagged

Cat.No. : PDK2-29162TH
Product Overview : RecombinantHuman PDK2 amino acids 16 - 407 with N-terminal His tag.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein length : 392 amino acids
Conjugation : HIS
Tissue specificity : Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.
Form : Liquid
Storage buffer : pH: 7.50Constituents:0.08% DTT, 0.14% Sodium phosphate, 1.46% Sodium chloride, 30% Glycerol, 0.015% EDTA, 0.05% Triton-X-100
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the PDK/BCKDK protein kinase family.Contains 1 histidine kinase domain.
Gene Name : PDK2 pyruvate dehydrogenase kinase, isozyme 2 [ Homo sapiens ]
Official Symbol : PDK2
Synonyms : PDK2; pyruvate dehydrogenase kinase, isozyme 2; pyruvate dehydrogenase kinase, isoenzyme 2; PDHK2;
Gene ID : 5164
mRNA Refseq : NM_001199898
Protein Refseq : NP_001186827
MIM : 602525
Uniprot ID : Q15119
Chromosome Location : 17q21.33
Pathway : B Cell Receptor Signaling Pathway, organism-specific biosystem; Metabolism, organism-specific biosystem; Pyruvate metabolism, organism-specific biosystem; Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystem; Regulation of pyruvate dehydrogenase (PDH) complex, organism-specific biosystem;
Function : ATP binding; nucleotide binding; protein kinase activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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