Recombinant Human PDK2, His-tagged

• Cat.No.: PDK2-651H
• Product Overview: Recombinant Human PDK2 with a His tag is expressed inBacteriaand column-purified.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: PDH kinases (PDK"s) deactivate PDH by reversible phosphorylation. In humans and rodents, 4 PDK"s are present in an organ-dependent manner. In all cases, PDK"s are physically part of the PDH complex (binding via lipoyl domain 2 of E2), and they phosphorylate the E1 subunit at 3 specific serine residues. PDH phosphatases remove the phosphorylation and restore activity of PDH.
• Storage: Store at -80°C.

Gene Information

• Gene Name: PDK2 pyruvate dehydrogenase kinase, isozyme 2 [ Homo sapiens ]
• Synonyms: PDK2; pyruvate dehydrogenase kinase, isozyme 2; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 2; pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial; PDHK2; EC 2.7.11.2
• Gene ID: 5164
• mRNA Refseq: NM_002611
• Protein Refseq: NP_002602
• MIM: 602525
• UniProt ID: Q15119
• Chromosome Location: 17q21.33
• Pathway: Integration of energy metabolism; Pyruvate metabolism and Citric Acid (TCA) cycle
• Function: ATP binding; nucleotide binding; protein heterodimerization activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; protein homodimerization activity; transferase activity; two-component sensor activity