Recombinant Human PPARA, His-tagged

• Cat.No.: PPARA-29987TH
• Product Overview: Recombinant full length Human PPAR alpha with His tag, Predicted MWt 52 kDa.

Specification

• Description: Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Skeletal muscle, liver, heart and kidney.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain.

Gene Information

• Gene Name: PPARA peroxisome proliferator-activated receptor alpha [ Homo sapiens ]
• Official Symbol: PPARA
• Synonyms: PPARA; peroxisome proliferator-activated receptor alpha; peroxisome proliferative activated receptor, alpha , PPAR; hPPAR; NR1C1
• Gene ID: 5465
• mRNA Refseq: NM_001001928
• Protein Refseq: NP_001001928
• Uniprot ID: Q07869
• Chromosome Location: 22q12-q13.1
• Pathway: Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Gene Expression, organism-specific biosystem; Circadian Clock, organism-specific biosystem
• Function: DNA binding; MDM2 binding; drug binding; ligand-dependent nuclear receptor activity; ligand-regulated transcription factor activity