Recombinant Human DNMT1, GST-tagged

• Cat.No.: DNMT1-511H
• Product Overview: Recombinant Human DNMT1, (a-a 2-1632), with N-terminal GST tag expressed inbaculovirus. MW= 211 kDa.

Specification

• Cat. No.: DNMT1-511H
• Description: DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities.
• Source: Baculovirus.
• Purity: >50%.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol.
• Stability: >6 months at –80°C.

Gene Information

• Gene Name: DNMT1 DNA (cytosine-5-)-methyltransferase 1 [ Homo sapiens ]
• Synonyms: DNMT1; DNA (cytosine-5-)-methyltransferase 1; AIM; DNMT; MCMT; CXXC9; FLJ16293; MGC104992; CXXC finger protein 9; DNA methyltransferase 1; EC 2.1.1.37; Dnmt1; DNA methyltransferase HsaI; DNA MTase HsaI; M.HsaI; CXXC-type zinc finger protein 9
• Gene ID: 1786
• mRNA Refseq: NM_001130823
• Protein Refseq: NP_001124295
• MIM: 126375
• UniProt ID: P26358
• Chromosome Location: 19p13.2
• Pathway: Cysteine and methionine metabolism; Metabolic pathways
• Function: DNA (cytosine-5-)-methyltransferase activity; DNA binding; metal ion binding; transcription factor binding; transferase activity; zinc ion binding