"QDPR" Related Products

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Recombinant Human QDPR, His-tagged

Cat.No.: QDPR-30230TH
Product Overview: Recombinant full length Human QDPR with an N terminal His tag; 267 amino acids with the tag; observed mwt: 28.2 kDa.
Description: This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin.This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations.Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase.
Protein length: 244 amino acids
Conjugation: HIS
Molecular Weight: 28.200kDa inclusive of tags
Source: E. coli
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: pH: 8.00Constituents:10% Glycerol, 0.32% Tris HCl, 0.04% DTT
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMGSMAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSFTEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELTPAYF
Sequence Similarities: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Gene Name: QDPR quinoid dihydropteridine reductase [ Homo sapiens ]
Official Symbol: QDPR
Synonyms: QDPR; quinoid dihydropteridine reductase; dihydropteridine reductase; 6; 7 dihydropteridine reductase; DHPR; PKU2; SDR33C1; short chain dehydrogenase/reductase family 33C; member 1;
Gene ID: 5860
mRNA Refseq: NM_000320
Protein Refseq: NP_000311
MIM: 612676
Uniprot ID: P09417
Chromosome Location: 4p15.31
Pathway: Folate biosynthesis, organism-specific biosystem; Folate biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem;
Function: 6,7-dihydropteridine reductase activity; NADH binding; NADPH binding; electron carrier activity; nucleotide binding;

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