Recombinant Human QDPR, His-tagged
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Cat.No. : | QDPR-30230TH |
Product Overview : | Recombinant full length Human QDPR with an N terminal His tag; 267 amino acids with the tag; observed mwt: 28.2 kDa. |
Description : | This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin.This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations.Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. |
Protein length : | 244 amino acids |
Conjugation : | HIS |
Molecular Weight : | 28.200kDa inclusive of tags |
Source : | E. coli |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | pH: 8.00Constituents:10% Glycerol, 0.32% Tris HCl, 0.04% DTT |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MGSMAAAAAA GEARRVLVYG GRGALGSRCV QAFRARNWWV ASVDVVENEE ASASIIVKMT DSFTEQADQV TAEVGKLLGE EKVDAILCVA GGWAGGNAKS KSLFKNCDLM WKQSIWTSTI SSHLATKHLK EGGLLTLAGA KAALDGTPGM IGYGMAKGAV HQLCQSLAGK NSGMPPGAAA IAVLPVTLDT PMNRKSMPEA DFSSWTPLEF LVETFHDWIT GKNRPSSGSL IQVVTTEGRT ELTPAYF |
Sequence Similarities : | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Gene Name : | QDPR quinoid dihydropteridine reductase [ Homo sapiens ] |
Official Symbol : | QDPR |
Synonyms : | QDPR; quinoid dihydropteridine reductase; dihydropteridine reductase; 6; 7 dihydropteridine reductase; DHPR; PKU2; SDR33C1; short chain dehydrogenase/reductase family 33C; member 1; |
Gene ID : | 5860 |
mRNA Refseq : | NM_000320 |
Protein Refseq : | NP_000311 |
MIM : | 612676 |
Uniprot ID : | P09417 |
Chromosome Location : | 4p15.31 |
Pathway : | Folate biosynthesis, organism-specific biosystem; Folate biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; |
Function : | 6,7-dihydropteridine reductase activity; NADH binding; NADPH binding; electron carrier activity; nucleotide binding; |
◆ Recombinant Protein
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QDPR-3613H | Recombinant Human QDPR, His-tagged | +Inquiry |
QDPR-679H | Recombinant Human QDPR Protein, His-tagged | +Inquiry |
QDPR-2090H | Recombinant Human QDPR, His-tagged | +Inquiry |
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◆ Lysates
QDPR-520HCL | Recombinant Human QDPR lysate | +Inquiry |
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