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Recombinant Rat Growth Hormone Receptor

Cat. No.: Ghr-1792R
Description: Growth hormone receptor, also known as GHR is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature (proportional dwarfism).
Molecular Weight: The predicted molecular weight of Recombinant Rat GHR is Mr 55.1 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 65-80 kDa.
Source: NSO Cells.
State Of Matter: Lyophilized.
Purity: >90% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: Ghr growth hormone receptor [ Rattus norvegicus ]
Synonyms: Ghr; growth hormone receptor; GHR/BP; MGC124963; MGC156665; growth hormone receptor/binding protein
Gene ID: 25235
mRNA Refseq: NM_017094
Protein Refseq: NP_058790
UniProt ID: P16310
Chromosome Location: 2q16
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Neuroactive ligand-receptor interaction
Function: SH2 domain binding; growth hormone receptor activity; peptide hormone binding; phosphate binding; protein binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; receptor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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