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Recombinant Human RIPK2

Cat.No. : RIPK2-29983TH
Product Overview : Recombinant fragment, corresponding to amino acids 1-299 of Human RIP2, was expressed by baculovirus in Sf9 insect cells using a N-terminal tag, MW 59 kDa.
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  • Gene Information
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Description : This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.
Tissue specificity : Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.Contains 1 CARD domain.Contains 1 protein kinase domain.
Gene Name : RIPK2 receptor-interacting serine-threonine kinase 2 [ Homo sapiens ]
Official Symbol : RIPK2
Synonyms : RIPK2; receptor-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; RICK; RIP2;
Gene ID : 8767
mRNA Refseq : NM_003821
Protein Refseq : NP_003812
MIM : 603455
Uniprot ID : O43353
Chromosome Location : 8q21
Pathway : Activated TLR4 signalling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Downstream TCR signaling, organism-specific biosystem;
Function : ATP binding; CARD domain binding; CARD domain binding; LIM domain binding; non-membrane spanning protein tyrosine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does RIPK2 play in the inflammatory response, particularly in the context of autoimmune diseases? 06/11/2020

RIPK2 plays a significant role in driving inflammatory responses, implicated in autoimmune disease mechanisms.

How does RIPK2 mediate signal transduction in the NOD1 and NOD2 pathways involved in innate immunity? 04/30/2020

RIPK2 is crucial in NOD1/NOD2 signaling, activating innate immune responses against microbial intrusions.

How do alterations in RIPK2 expression or signaling affect cancer development and progression? 12/29/2019

Changes in RIPK2 signaling can impact cancer development, influencing tumor cell survival and immune interactions.

How does RIPK2 contribute to the regulation of NF-κB activation and cytokine production? 02/04/2019

RIPK2 regulates NF-κB activation and cytokine production, crucial for immune response and inflammation.

What are the mechanisms by which RIPK2 modulates the host defense against bacterial pathogens? 03/30/2018

RIPK2 modulates defense mechanisms against bacterial pathogens, coordinating immune signaling and responses.

How does RIPK2 influence cell survival and apoptosis, especially under conditions of stress or infection? 03/24/2018

RIPK2 influences cell survival and apoptosis decisions, particularly in response to stress or microbial infection.

What is the impact of RIPK2 dysregulation on the development and progression of inflammatory bowel disease (IBD)? 02/21/2018

Dysregulation of RIPK2 is linked to IBD, affecting intestinal inflammation and immune responses.

Customer Reviews (3)

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Reviews
12/13/2019

    Precise mass spectrometry analysis, key for our proteomics investigations.

    04/07/2019

      Dependable protein purification, consistently delivers high yield and purity.

      11/23/2018

        Great antibody validation, enhances our immunoprecipitation success.

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