Native Human SERPINF2

• Cat.No.: SERPINF2-27145TH
• Product Overview: Full length protein, corresponding to amino acids 40-491 of Human Alpha 2 Antiplasmin; 452 amino acids, 67 kDa.

Specification

• Description: This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene.
• Species: Human
• Form: Liquid
• Molecular Mass: 67 kDa
• Protein length: 452 amino acids
• Purity: >95% by SDS-PAGE.
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80°C . Avoid freeze / thaw cycles.
• Storage Buffer: Preservative: NoneConstituents: 7.5mM Potassium chloride, 50mM Potassium phosphate, 0.075mM EDTA, pH 7.4

Gene Information

• Gene Name: SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 [ Homo sapiens ]
• Official Symbol: SERPINF2
• Synonyms: SERPINF2; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; PLI, serine (or cysteine) proteinase inhibitor, clade F (alpha 2 antiplasmin, pigment epithelium derived factor), member 2; alpha-2-antiplas
• Gene ID: 5345
• mRNA Refseq: NM_000934
• Protein Refseq: NP_000925
• MIM: 613168
• UniProt ID: P08697
• Chromosome Location: 17pter-p12
• Pathway: Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Dissolution of Fibrin Clot, organism-specific biosystem; Hemostasis, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem
• Function: endopeptidase inhibitor activity; eukaryotic cell surface binding; protease binding; protein binding; protein homodimerization activity; serine-type endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity