Native Human SNCA
Cat.No. : | SNCA-27339TH |
Product Overview : | A deletion mutant: MEQVTNVGGA V VTGVTAVA QK TVEGAGS IAA ATGFVK KDQL GKNEE GAPQE GILE DMPVDP DNE AYEMPSE EG YQDYEPEA, corresponding to amino acids 61-140 of Human alpha Synuclein. 81 amino acids, MW 9460 Da. Additional amino acid(Met) is attached at the N- |
- Specification
- Gene Information
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Description : | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. |
Source : | E. coli |
Tissue specificity : | Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 0.1M Sodium chloride, 20mM Tris HCl, pH 7.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MEQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA |
Sequence Similarities : | Belongs to the synuclein family. |
Gene Name : | SNCA synuclein, alpha (non A4 component of amyloid precursor) [ Homo sapiens ] |
Official Symbol : | SNCA |
Synonyms : | SNCA; synuclein, alpha (non A4 component of amyloid precursor); PARK1, PARK4, Parkinson disease (autosomal dominant, Lewy body) 4; alpha-synuclein; alpha synuclein; NACP; PD1; |
Gene ID : | 6622 |
mRNA Refseq : | NM_000345 |
Protein Refseq : | NP_000336 |
MIM : | 163890 |
Uniprot ID : | P37840 |
Chromosome Location : | 4q21.3-q22 |
Pathway : | Alpha-synuclein signaling, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyloids, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; |
Function : | Hsp70 protein binding; alpha-tubulin binding; arachidonic acid binding; calcium ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; |
Products Types
◆ Recombinant Protein | ||
Snca-1372R | Recombinant Rat Snca Protein, GST-tagged | +Inquiry |
SNCA-8524M | Recombinant Mouse SNCA Protein, His (Fc)-Avi-tagged | +Inquiry |
SNCA-02H | Recombinant Human SNCA Protein | +Inquiry |
SNCA-2744H | Recombinant Human SNCA protein(11-110 aa), C-His-tagged | +Inquiry |
Snca-5996M | Recombinant Mouse Snca Protein, Myc/DDK-tagged | +Inquiry |
◆ Native Protein | ||
SNCA-27341TH | Native Human SNCA | +Inquiry |
SNCA-27345TH | Native Human SNCA | +Inquiry |
SNCA-27342TH | Native Human SNCA | +Inquiry |
◆ Lysates | ||
SNCA-1634HCL | Recombinant Human SNCA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, elevated levels of SNCA protein in cerebrospinal fluid can be indicative of Parkinson's disease.
Therapies may include reducing SNCA aggregation or preventing its misfolding.
Yes, certain mutations in the SNCA gene are associated with familial Parkinson's disease.
Aggregates of misfolded SNCA protein are implicated in various neurodegenerative diseases, including Parkinson's disease.
Yes, several clinical trials are exploring treatments targeting SNCA protein in Parkinson's disease.
Customer Reviews (3)
Write a reviewIts integrity and reliability make it an ideal choice to address the specific objectives of my research.
Their profound knowledge and expertise will undoubtedly help me overcome any challenges that arise, and their prompt assistance ensures a seamless progression of my research.
In addition to the exceptional quality of the protein, the manufacturer's support extends beyond the product itself.
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