Cat.No. :	SNCA-27339TH
Product Overview :	A deletion mutant: MEQVTNVGGA V VTGVTAVA QK TVEGAGS IAA ATGFVK KDQL GKNEE GAPQE GILE DMPVDP DNE AYEMPSE EG YQDYEPEA, corresponding to amino acids 61-140 of Human alpha Synuclein. 81 amino acids, MW 9460 Da. Additional amino acid(Met) is attached at the N-
Description :	Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
Source :	E. coli
Tissue specificity :	Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Form :	Liquid
Purity :	>95% by SDS-PAGE
Storage buffer :	Preservative: NoneConstituents: 0.1M Sodium chloride, 20mM Tris HCl, pH 7.5
Storage :	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids :	MEQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Sequence Similarities :	Belongs to the synuclein family.

Gene Name :	SNCA synuclein, alpha (non A4 component of amyloid precursor) [ Homo sapiens ]
Official Symbol :	SNCA
Synonyms :	SNCA; synuclein, alpha (non A4 component of amyloid precursor); PARK1, PARK4, Parkinson disease (autosomal dominant, Lewy body) 4; alpha-synuclein; alpha synuclein; NACP; PD1;
Gene ID :	6622
mRNA Refseq :	NM_000345
Protein Refseq :	NP_000336
MIM :	163890
Uniprot ID :	P37840
Chromosome Location :	4q21.3-q22
Pathway :	Alpha-synuclein signaling, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyloids, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem;
Function :	Hsp70 protein binding; alpha-tubulin binding; arachidonic acid binding; calcium ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process;

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