Cat.No. : |
SNCA-27339TH |
Product Overview : |
A deletion mutant: MEQVTNVGGA V VTGVTAVA QK TVEGAGS IAA ATGFVK KDQL GKNEE GAPQE GILE DMPVDP DNE AYEMPSE EG YQDYEPEA, corresponding to amino acids 61-140 of Human alpha Synuclein. 81 amino acids, MW 9460 Da. Additional amino acid(Met) is attached at the N- |
Description : |
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. |
Source : |
E. coli |
Tissue specificity : |
Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals. |
Form : |
Liquid |
Purity : |
>95% by SDS-PAGE |
Storage buffer : |
Preservative: NoneConstituents: 0.1M Sodium chloride, 20mM Tris HCl, pH 7.5 |
Storage : |
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequences of amino acids : |
MEQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA |
Sequence Similarities : |
Belongs to the synuclein family. |