Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), 1-95

• Cat.No.: SNCA-295H
• Product Overview: Recombinant Human α-Synuclein protein produced in E.Coli encodes 95 (1-95) amino acids and has a molecular mass of 9.3 kDa.

Specification

• Cat. No.: SNCA-295H
• Description: A deletion mutant ofa-synuclein (amino acids 1-95), which contains the N-terminal amphipathic domain and NAC region. a-synuclein 1-95 was overexpressed in E. coli and the recombinant protein was purified to apparent homogeneity by using conventional column chromatography techniques.
• Source: E.coli.
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 100 mM NaCl.
• Molecular Weight: 9.3 kDa (95 aa).
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by BCA assay).
• Sequence: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFV
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Tag: Non

Gene Information

• Gene Name: SNCA
• Synonyms: SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; MGC110988; alpha-synuclein, isoform NACP140; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; alpha-synuclein; OTTHUMP00000161559; OTTHUMP00000161561; non A-beta component of AD amyloid; synuclein, alpha (non A4 component of amyloid precursor); Synuclein, alpha (non-Abeta component of Alzheimer"s disease amyloid precursor protein: NACP).
• Gene ID: 6622
• mRNA Refseq: NM_000345.3
• Protein Refseq: NP_000336.1
• MIM: 163890
• UniProt ID: P37840
• Chromosome Location: 4q21
• Pathway: Alzheimer"s disease;Neurodegenerative Disorders;Parkinson"s disease.
• Function: Hsp70 protein binding;alpha-tubulin binding;dynein binding;histone binding;kinesin binding;tau protein binding;transferrin transmembrane transporter activity.

Reviews

08/31/2020

Its integrity and reliability make it an ideal choice to address the specific objectives of my research.

03/12/2020

Their profound knowledge and expertise will undoubtedly help me overcome any challenges that arise, and their prompt assistance ensures a seamless progression of my research.

10/16/2017

In addition to the exceptional quality of the protein, the manufacturer's support extends beyond the product itself.

Q&As

Can SNCA protein levels in cerebrospinal fluid be used as a diagnostic marker for Parkinson's disease?

Yes, elevated levels of SNCA protein in cerebrospinal fluid can be indicative of Parkinson's disease.

What potential therapeutic strategies target SNCA protein for Parkinson's disease treatment?

Therapies may include reducing SNCA aggregation or preventing its misfolding.

Are there any genetic mutations related to SNCA protein that increase the risk of Parkinson's disease?

Yes, certain mutations in the SNCA gene are associated with familial Parkinson's disease.

How is SNCA protein associated with neurodegenerative diseases?

Aggregates of misfolded SNCA protein are implicated in various neurodegenerative diseases, including Parkinson's disease.

Are there any ongoing clinical trials investigating SNCA-related therapies?

Yes, several clinical trials are exploring treatments targeting SNCA protein in Parkinson's disease.