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Recombinant Human AKR1A1

Cat.No. : AKR1A1-485H
Product Overview : Recombinant humanAlcohol dehydrogenase was expressed inE.coliand purified by using conventional chromatography techniques. MW =36.5 kDa (325aa).
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Cat. No. : AKR1A1-485H
Description : Alcohol dehydrogenase [NADP+] (AKR1A1) is a member of the aldo/keto reductase superfamily and catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. This protein is closely related (65% identity) to aldose reductase, an enzyme involved in the pathogenesis of some diabetic and galactosemic complications. It plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
Source : E.coli.
Amino Acid Sequence : MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEKYGRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV PMLTVDGKRV PRDAGHPLYP FNDPY
Form : Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 50mM NaCl, 10% glycerol.
Purity : > 90% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) [ Homo sapiens ]
Synonyms : AKR1A1; aldo-keto reductase family 1, member A1 (aldehyde reductase); ALR; ARM; DD3; ALDR1; MGC1380; MGC12529; OTTHUMP00000009240; aldehyde reductase; alcohol dehydrogenase; dihydrodiol dehydrogenase 3; EC 1.1.1.2; Alcohol dehydrogenase [NADP+]; Aldo-keto reductase family 1 member A1; OTTHUMP00000009241; aldo-keto reductase family 1, member A1
Gene ID : 10327
mRNA Refseq : NM_006066
Protein Refseq : NP_006057
MIM : 103830
UniProt ID : P14550
Chromosome Location : 1p33-p32
Pathway : Glycerolipid metabolismC; Glycolysis / Gluconeogenesis; Metabolic pathways
Function : L-glucuronate reductase activity; alcohol dehydrogenase (NADP+) activity; aldehyde reductase activity; electron carrier activity; oxidoreductase activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (12)

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What diseases is AKR1A1 protein associated with? 04/08/2023

AKR1A1 protein is involved in many diseases, such as metabolic diseases, tumors, autoimmune diseases, etc.

Can you briefly describe the structure and function of AKR1A1 protein? 03/20/2022

The AKR1A1 protein is a REDOX enzyme capable of reducing and oxidizing a variety of compounds, such as toxins and drugs, to maintain the stability of the internal and external environment of the cell.

In what medical fields are inhibitors of AKR1A1 protein applied? 11/30/2021

AKR1A1 protein inhibitors have been used in the treatment of leukemia, AIDS, diabetes and other diseases.

In what parts or cells of the human body does AKR1A1 protein primarily act? 07/25/2021

This protein mainly plays a role in liver, lung, eye, intestine, kidney, prostate, stomach and other parts and a variety of cells, such as germ cells, neurons, alveolar epithelial cells, liver cells and so on.

What metabolic processes does AKR1A1 protein play an important role in? 05/07/2021

AKR1A1 protein plays an important role in various metabolic processes, such as the metabolism of vitamin A and various hormones.

AKR1A1 protein is closely related to the metabolism of which drugs? 02/28/2021

AKR1A1 protein is associated with the metabolism and toxicity of many drugs, such as phenol, pyruvate, acetaminophen, etc.

Which treatments are associated with AKR1A1 protein expression levels? 12/21/2020

The expression level of AKR1A1 protein is related to the therapeutic effect of certain drugs on diseases.

The high expression of AKR1A1 protein is related to the occurrence and development of which diseases? 12/06/2020

The high expression of AKR1A1 protein is associated with the occurrence and development of many diseases, such as tumors, metabolic diseases, and autoimmune diseases.

Do mutations in AKR1A1 protein cause disease? 09/12/2020

AKR1A1 protein gene mutation has a certain relationship with the occurrence of some diseases, such as tumors, metabolic diseases and so on.

Which cell growth and apoptosis processes does AKR1A1 protein play a role in? 06/25/2019

AKR1A1 protein plays a role in tumor cell growth and apoptosis.

Have any studies found any difference in the expression level of AKR1A1 protein in liver cancer and other tumors? 06/01/2019

The expression level of AKR1A1 in liver cancer cells and other tumor cells is different from that in normal cells and is closely related to the proliferation and metastasis of tumor cells.

How does AKR1A1 function differently from other proteins? 04/11/2019

AKR1A1 protein plays a more prominent role in metabolic reduction than other proteins, and its deposition and expression levels are closely related to the occurrence and development of a variety of diseases.

Customer Reviews (4)

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Reviews
05/20/2023

    Have high sensitivity and specificity in biosensor preparation.

    05/13/2022

      It promoted cell growth and proliferation.

      04/29/2021

        Good selectivity for specific disease-related targets.

        05/19/2020

          Iinhibitory or killing effect on specific pathogens.

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