Recombinant Human AKR1A1 AKR1A1-485H

Recombinant Human AKR1A1

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Recombinant Human AKR1A1

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Cat. No. : AKR1A1-485H
Product Overview : Recombinant humanAlcohol dehydrogenase was expressed inE.coliand purified by using conventional chromatography techniques. MW =36.5 kDa (325aa).
Description : Alcohol dehydrogenase [NADP+] (AKR1A1) is a member of the aldo/keto reductase superfamily and catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. This protein is closely related (65% identity) to aldose reductase, an enzyme involved in the pathogenesis of some diabetic and galactosemic complications. It plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
Source : E.coli.
Amino Acid Sequence : MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEKYGRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV PMLTVDGKRV PRDAGHPLYP FNDPY
Form : Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 50mM NaCl, 10% glycerol.
Purity : > 90% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
PDB rendering based on 1ae4. :

Gene Name : AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) [ Homo sapiens ]
Synonyms : AKR1A1; aldo-keto reductase family 1, member A1 (aldehyde reductase); ALR; ARM; DD3; ALDR1; MGC1380; MGC12529; OTTHUMP00000009240; aldehyde reductase; alcohol dehydrogenase; dihydrodiol dehydrogenase 3; EC 1.1.1.2; Alcohol dehydrogenase [NADP+]; Aldo-keto reductase family 1 member A1; OTTHUMP00000009241; aldo-keto reductase family 1, member A1
Gene ID : 10327
mRNA Refseq : NM_006066
Protein Refseq : NP_006057
MIM : 103830
UniProt ID : P14550
Chromosome Location : 1p33-p32
Pathway : Glycerolipid metabolismC; Glycolysis / Gluconeogenesis; Metabolic pathways
Function : L-glucuronate reductase activity; alcohol dehydrogenase (NADP+) activity; aldehyde reductase activity; electron carrier activity; oxidoreductase activity; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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