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Recombinant Human Delta-like 1 Homolog (Drosophila), FLAG-tagged

Cat.No. : DLK1-2079H
Product Overview : Recombinant HumanDLK1 is produced inHEK 293 Cells. Signal peptide and extracellular domain of human Dlk1 (aa 1-303) are fused at the C-terminus to a FLAG-tag.
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  • Gene Information
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Cat. No. : DLK1-2079H
Description : This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
Source : HEK 293 Cells.
Concentration : ~1mg/ml.
Formulation : Liquid. 0.2µm-filtered solution in PBS.
Endotoxin Content : <0.1EU/µg protein (LAL-test).
Purity : ≥90% (SDS-PAGE).
Storage : Working aliquots are stable for up to 3 months when stored at -20°C.
Handling : After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Gene Name : DLK1 delta-like 1 homolog (Drosophila) [ Homo sapiens ]
Synonyms : DLK1; delta-like 1 homolog (Drosophila); DLK; FA1; ZOG; pG2; PREF1; Pref-1; protein delta homolog 1; DLK-1; secredeltin; fetal antigen 1; preadipocyte factor 1
Gene ID : 8788
mRNA Refseq : NM_003836
Protein Refseq : NP_003827
MIM : 176290
UniProt ID : P80370
Chromosome Location : 14q32
Function : molecular_function; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does DLK1 protein contribute to cell senescence? 11/12/2021

DLK1 has been found to play a role in cellular senescence, and understanding this process may have implications for aging-related research.

Are there ongoing clinical trials involving DLK1 protein? 04/20/2021

Yes, there are clinical trials exploring the therapeutic potential of targeting DLK1 in cancer treatment and regenerative medicine.

How is DLK1 protein linked to adipogenesis? 12/28/2020

DLK1 is involved in the regulation of adipocyte differentiation, and understanding its role may have implications for obesity-related research.

How does DLK1 protein impact stem cell differentiation? 12/08/2020

DLK1 is involved in the regulation of stem cell differentiation, making it a potential target for therapeutic applications in regenerative medicine.

Can manipulating DLK1 expression have therapeutic benefits? 05/21/2019

Modulating DLK1 expression holds promise for therapeutic interventions, such as controlling cell growth in cancer or enhancing tissue regeneration.

Customer Reviews (3)

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Reviews
10/14/2022

    In addition to these experimental benefits, the manufacturer of DLK1 protein plays a vital role in supporting researchers.

    06/15/2022

      DLK1 protein demonstrates exceptional stability and consistency, ensuring reliable and reproducible results throughout the duration of the trial.

      01/24/2018

        DLK1 protein exhibits high bioactivity, enabling efficient and effective interactions with its molecular targets.

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