"DLK1" Related Products


Recombinant Human Delta-like 1 Homolog (Drosophila), FLAG-tagged

Cat. No.: DLK1-2079H
Product Overview: Recombinant HumanDLK1 is produced inHEK 293 Cells. Signal peptide and extracellular domain of human Dlk1 (aa 1-303) are fused at the C-terminus to a FLAG-tag.
Description: This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
Source: HEK 293 Cells.
Concentration: ~1mg/ml.
Formulation: Liquid. 0.2µm-filtered solution in PBS.
Endotoxin Content: <0.1EU/µg protein (LAL-test).
Purity: ≥90% (SDS-PAGE).
Storage: Working aliquots are stable for up to 3 months when stored at -20°C.
Handling: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Gene Name: DLK1 delta-like 1 homolog (Drosophila) [ Homo sapiens ]
Synonyms: DLK1; delta-like 1 homolog (Drosophila); DLK; FA1; ZOG; pG2; PREF1; Pref-1; protein delta homolog 1; DLK-1; secredeltin; fetal antigen 1; preadipocyte factor 1
Gene ID: 8788
mRNA Refseq: NM_003836
Protein Refseq: NP_003827
MIM: 176290
UniProt ID: P80370
Chromosome Location: 14q32
Function: molecular_function; protein binding

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