|Product Overview:||Recombinant Human PDP2 with a His tag is expressed inBacteriaand column-purified.|
|Description:||PDH kinases (PDK"s) deactivate PDH by reversible phosphorylation. In humans and rodents, 4 PDK"s are present in an organ-dependent manner. In all cases, PDK"s are physically part of the PDH complex (binding via lipoyl domain 2 of E2), and they phosphorylate the E1 subunit at 3 specific serine residues. PDH phosphatases remove the phosphorylation and restore activity of PDH.|
|Storage:||Store at -80°C.|
|Gene Name:||PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 [ Homo sapiens ]|
|Synonyms:||PDP2; pyruvate dehyrogenase phosphatase catalytic subunit 2; PDP 2; PDPC 2; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; protein phosphatase 2C, magnesium-dependent, catalytic subunit 2; pyruvate dehydrogenase phosphatase catalytic subunit 2; pyruvate dehydrogenase phosphatase isoenzyme 2; pyruvate dehydrogenase phosphatase, catalytic subunit 2; PPM2C2; KIAA1348|
|Pathway:||Integration of energy metabolism; Pyruvate metabolism and Citric Acid (TCA) cycle|
|Function:||[pyruvate dehydrogenase (lipoamide)] phosphatase activity; calcium ion binding; hydrolase activity; magnesium-dependent protein serine/threonine phosphatase activity; protein complex binding|
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