Expand Expand| Cat. No. : | F11R-788H |
| Product Overview : | Recombinant Human F11R protein (Gln 24- Tyr 213), fused with the His tag at the N-terminus, was expressed inHuman Cells. |
| Description : | As a typeⅠtransmembrane receptor belonging to the immunoglobulin superfamily, the human JAM-A, also known as platelet adhesion molecule 1(PAM-1) and platelet F11 receptor, is the firstly identified member of the Junctional Adhesion Molecule (JAM) family comprising at least three members. JAM-A is specifically localized in tight junctions of epithelial and endothelial cells and is involved in the regulation of junctional integrity and permeability by serving as a physical barrier in a homophilic manner. JAM-A is also expressed on the surface of hematopoeitic cells, such as platelets and leukocytes, and acts as a ligand for integrin LFA-1 or a platelet receptor, consequently plays key roles in a variety of cellular processes, including platelet aggregation, leukocyte transmigration, and angiogenesis. In addition, JAM-A has also been implicated in the attachment of reovirus that causes diarrhea in human. |
| Source : | Human Cells. |
| Molecular Mass : | The mature recombinant human JAM-A/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer comprises 453 amino acids and has a calculated molecular mass of 50 kDa. As a result of glycosylation, the rh JAM-A/Fc monomer migrates as an approximately 61kDa protein in SDS-PAGE under reducing conditions. |
| Predicted N Terminal : | Ser 28. |
| Purity : | > 95% as determined by SDS-PAGE. |
| Formulation : | Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH7.5. |
| Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Reconstitution : | A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |
| Storage And Stability : | Samples are stable for up to twelve months from date of receipt at -700C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Gene Name : | F11R F11 receptor [ Homo sapiens ] |
| Synonyms : | F11R; F11 receptor; JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1; junctional adhesion molecule 1; Junctional adhesion molecule A; JAM-A; Junctional adhesion molecule 1; Platelet adhesion molecule 1; JAM-1; OTTHUMP00000027880; OTTHUMP00000027881; CD321 antigen; Platelet F11 receptor |
| Gene ID : | 50848 |
| mRNA Refseq : | NM_016946 |
| Protein Refseq : | NP_058642 |
| MIM : | 605721 |
| UniProt ID : | Q9Y624 |
| Chromosome Location : | 1q21.2-q21.3 |
| Pathway : | Cell adhesion molecules (CAMs); Epithelial cell signaling in Helicobacter pylori infection; Leukocyte transendothelial migration; Tight junction; Cell-cell adhesion systems; Hemostasis; Integrin cell surface interactions; Signaling in Immune system |
| Function : | protein binding |
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