Recombinant Human F11 Receptor, His-tagged
Cat.No. : | F11R-788H |
Product Overview : | Recombinant Human F11R protein (Gln 24- Tyr 213), fused with the His tag at the N-terminus, was expressed inHuman Cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | F11R-788H |
Description : | As a typeⅠtransmembrane receptor belonging to the immunoglobulin superfamily, the human JAM-A, also known as platelet adhesion molecule 1(PAM-1) and platelet F11 receptor, is the firstly identified member of the Junctional Adhesion Molecule (JAM) family comprising at least three members. JAM-A is specifically localized in tight junctions of epithelial and endothelial cells and is involved in the regulation of junctional integrity and permeability by serving as a physical barrier in a homophilic manner. JAM-A is also expressed on the surface of hematopoeitic cells, such as platelets and leukocytes, and acts as a ligand for integrin LFA-1 or a platelet receptor, consequently plays key roles in a variety of cellular processes, including platelet aggregation, leukocyte transmigration, and angiogenesis. In addition, JAM-A has also been implicated in the attachment of reovirus that causes diarrhea in human. |
Source : | Human Cells. |
Molecular Mass : | The mature recombinant human JAM-A/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer comprises 453 amino acids and has a calculated molecular mass of 50 kDa. As a result of glycosylation, the rh JAM-A/Fc monomer migrates as an approximately 61kDa protein in SDS-PAGE under reducing conditions. |
Predicted N Terminal : | Ser 28. |
Purity : | > 95% as determined by SDS-PAGE. |
Formulation : | Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH7.5. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Reconstitution : | A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |
Storage And Stability : | Samples are stable for up to twelve months from date of receipt at -700C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | F11R F11 receptor [ Homo sapiens ] |
Synonyms : | F11R; F11 receptor; JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1; junctional adhesion molecule 1; Junctional adhesion molecule A; JAM-A; Junctional adhesion molecule 1; Platelet adhesion molecule 1; JAM-1; OTTHUMP00000027880; OTTHUMP00000027881; CD321 antigen; Platelet F11 receptor |
Gene ID : | 50848 |
mRNA Refseq : | NM_016946 |
Protein Refseq : | NP_058642 |
MIM : | 605721 |
UniProt ID : | Q9Y624 |
Chromosome Location : | 1q21.2-q21.3 |
Pathway : | Cell adhesion molecules (CAMs); Epithelial cell signaling in Helicobacter pylori infection; Leukocyte transendothelial migration; Tight junction; Cell-cell adhesion systems; Hemostasis; Integrin cell surface interactions; Signaling in Immune system |
Function : | protein binding |
Products Types
◆ Recombinant Protein | ||
F11r-2899M | Recombinant Mouse F11r Protein, Myc/DDK-tagged | +Inquiry |
F11R-1044H | Recombinant Human F11R protein(Gln24-Tyr213), hFc-tagged | +Inquiry |
F11r-1448M | Recombinant Mouse F11r Protein, His-tagged | +Inquiry |
F11R-1832R | Recombinant Rat F11R Protein, His (Fc)-Avi-tagged | +Inquiry |
F11r-4032M | Recombinant Mouse F11r protein(Met1-Ala242), hFc-tagged | +Inquiry |
◆ Lysates | ||
F11R-2127MCL | Recombinant Mouse F11R cell lysate | +Inquiry |
F11R-1437RCL | Recombinant Rat F11R cell lysate | +Inquiry |
F11R-2741HCL | Recombinant Human F11R cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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