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Recombinant Human LCK, GST tagged

Cat.No. : LCK-776H
Product Overview : Recombinant Human LCK (NP_001036236.1) (Met 1-Pro 509), fused with the GST tag at the N-terminus, was produced in Baculovirus-Insect cells.
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Source : Baculovirus-Insect Cells
Species : Human
Tag : GST
Form : Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0, 0.5mM GSH, 0.1mM EGTA, 0.1mM EDTA, 0.5mM PMSF, 10% glycerol
Molecular Mass : The recombinant human LCK/GST chimera consists of 734 amino acids and predicts a molecular mass of 84.4 kDa. It migrates as an approximately 80 kDa band in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : LCK lymphocyte-specific protein tyrosine kinase [ Homo sapiens ]
Official Symbol : LCK
Gene ID : 3932
mRNA Refseq : NM_001042771
Protein Refseq : NP_001036236
MIM : 153390
UniProt ID : P06239

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does LCK play in the development and maturation of T cells in the thymus? 05/25/2022

LCK plays a vital role in the development and maturation of T cells in the thymus, especially during the processes of positive and negative selection, ensuring the generation of a functional and self-tolerant T-cell repertoire.

Can LCK activity be modulated by pharmacological agents? 02/24/2022

Yes, LCK activity can be modulated by several pharmacological agents, including kinase inhibitors like dasatinib, which have been explored for therapeutic purposes in various diseases.

How is LCK activation regulated post-translationally? 01/16/2022

LCK activation is regulated post-translationally through phosphorylation at specific tyrosine residues, with its activity being modulated by both activating and inhibitory phosphorylations.

What is the primary function of LCK in T-cell signaling? 07/16/2021

LCK is a pivotal Src family kinase that plays a crucial role in initiating T-cell receptor (TCR) signaling by phosphorylating key tyrosines on the CD3 and ζ-chains of the TCR complex.

How does LCK interact with other kinases in T-cell signaling pathways? 07/08/2020

LCK interacts with other kinases such as ZAP-70 and Fyn in T-cell signaling pathways, orchestrating a cascade of phosphorylation events that lead to T-cell activation.

Are there any known diseases or conditions associated with LCK dysregulation? 12/01/2018

Dysregulation of LCK has been associated with various conditions, including autoimmune diseases, immunodeficiencies, and certain leukemias.

How does LCK contribute to T-cell receptor (TCR) complex formation and activation? 08/14/2018

LCK contributes to TCR complex formation and activation by phosphorylating the immunoreceptor tyrosine-based activation motifs (ITAMs) on the TCR, facilitating the recruitment and activation of ZAP-70 kinase.

Customer Reviews (3)

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Reviews
04/24/2022

    Good stability, long shelf-life.

    10/29/2020

      Consistent quality across batches.

      03/11/2019

        Pure product, reliable results.

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