Cat. No. : | DRAP1-2670H |
Product Overview : | Recombinant Human DRAP1with a His tag is expressed inE. coli.MW: 28±5 KDa. |
Description : | Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. |
Source : | E. coli. |
Formulation : | 20% Glycerol solution at 0.20 mg/ml. |
Activity : | Interacts with TBP and prevents the TBP-IIB-IIA complex required for transcription. |
Storage : | Store at -80°C. At least 1 year at -80°C. |
Gene Name : | DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) [ Homo sapiens ] |
Synonyms : | DRAP1; DR1-associated protein 1 (negative cofactor 2 alpha); dr1-associated corepressor; negative co-factor 2-alpha; negative cofactor 2 alpha; NC2-alpha |
Gene ID : | 10589 |
mRNA Refseq : | NM_006442 |
Protein Refseq : | NP_006433 |
MIM : | 602289 |
UniProt ID : | Q14919 |
Chromosome Location : | 11q13.3 |
Pathway : | Cell Cycle, Mitotic; Nucleotide excision repair; DNA Repair; Gene Expression; HIV Infection; Transcription; mRNA Processing |
Function : | DNA binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity |
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