Recombinant Human DRAP1, His-tagged DRAP1-2670H

Recombinant Human DRAP1, His-tagged

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Recombinant Human DRAP1, His-tagged

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Cat. No. : DRAP1-2670H
Product Overview : Recombinant Human DRAP1with a His tag is expressed inE. coli.MW: 28±5 KDa.
Description : Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex.
Source : E. coli.
Formulation : 20% Glycerol solution at 0.20 mg/ml.
Activity : Interacts with TBP and prevents the TBP-IIB-IIA complex required for transcription.
Storage : Store at -80°C. At least 1 year at -80°C.
PDB rendering based on 1jfi. :

Gene Name : DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) [ Homo sapiens ]
Synonyms :
DRAP1; DR1-associated protein 1 (negative cofactor 2 alpha); dr1-associated corepressor; negative co-factor 2-alpha; negative cofactor 2 alpha; NC2-alpha
Gene ID : 10589
mRNA Refseq : NM_006442
Protein Refseq : NP_006433
MIM : 602289
UniProt ID : Q14919
Chromosome Location : 11q13.3
Pathway : Cell Cycle, Mitotic; Nucleotide excision repair; DNA Repair; Gene Expression; HIV Infection; Transcription; mRNA Processing
Function : DNA binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity

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