Cat. No. :	DRAP1-2670H
Product Overview :	Recombinant Human DRAP1with a His tag is expressed inE. coli.MW: 28±5 KDa.
Description :	Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex.
Source :	E. coli.
Formulation :	20% Glycerol solution at 0.20 mg/ml.
Activity :	Interacts with TBP and prevents the TBP-IIB-IIA complex required for transcription.
Storage :	Store at -80°C. At least 1 year at -80°C.

Gene Name :	DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) [ Homo sapiens ]
Synonyms :	DRAP1; DR1-associated protein 1 (negative cofactor 2 alpha); dr1-associated corepressor; negative co-factor 2-alpha; negative cofactor 2 alpha; NC2-alpha
Gene ID :	10589
mRNA Refseq :	NM_006442
Protein Refseq :	NP_006433
MIM :	602289
UniProt ID :	Q14919
Chromosome Location :	11q13.3
Pathway :	Cell Cycle, Mitotic; Nucleotide excision repair; DNA Repair; Gene Expression; HIV Infection; Transcription; mRNA Processing
Function :	DNA binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity

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