|Product Overview:||Recombinant Human IL2 (Ala21-Thr153) with a 6His tag at the C-terminus was produced in HEK293 cell in an animal component free process under cGMP guidelines.|
|Description:||Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system，belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.|
|Bio-activity:||Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells.
The ED50 for this effect is typically 0.02-0.3ng/mL. Specific Activity of 1.0 x 10^7 IU/mg.
|AA Sequence:||APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKP LEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIIS TLTVDHHHHHH|
|Residual Host Cell DNA Content:||<10pg/mg|
|Residual Host Cell Protein Content:||<1ug/mg|
|Purity:||Greater than 95% as determined by reducing SDS-PAGE.|
|Usage:||Recommemnd working concentration: 30ng/ml or 300U/ml|
|Storage:||Lyophilized and reconstituted protein should be stored at -80 centigrade. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.|
|Reconstitution:||Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration >100μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
|Quality Statement:||Our GMP proteins are produced according to relevant sections of the following documents: WHO TRS, No. 822, 1992 Annex 1, Good Manufacturing Practices for Biological Products; USP Chapter 1043, Ancillary Materials for Cell, Gene and Tissue-Engineered Products and USP Chapter 92, Growth Factors and Cytokines Used in Cell Therapy Manufacturing.|
|Shipping:||The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.|
|Gene Name:||IL2 interleukin 2 [ Homo sapiens ]|
|Synonyms:||IL2; interleukin 2; interleukin-2; IL 2; T cell growth factor; TCGF; aldesleukin; IL-2; lymphokine|
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