Active Recombinant Human IL2, MIgG2a Fc-tagged

• Cat.No.: IL2-167H
• Product Overview: The extracellular domain of human IL-2(NP_000577.2) (Ala21-Thr153) (Cys145Ser) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO celL

Specification

• Description: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and Blymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also sharedby interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic,which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeteddisruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential roleof this gene in the immune response to antigenic stimuli
• Source: CHO cells
• Species: Human
• Tag: MIgG2a Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells.
• Molecular Mass: 44KDa (monomer)
• AA Sequence: (Ala21-Thr153) (Cys145Ser)
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: IL2 interleukin 2 [ Homo sapiens ]
• Official Symbol: IL2
• Synonyms: IL2; interleukin 2; interleukin-2; IL 2; T cell growth factor; TCGF; aldesleukin; involved in regulation of T-cell clonal expansion; IL-2; lymphokine
• Gene ID: 3558
• mRNA Refseq: NM_000586
• Protein Refseq: NP_000577
• MIM: 147680
• UniProt ID: P60568
• Chromosome Location: 4q26-q27
• Pathway: Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem
• Function: carbohydrate binding; cytokine activity; glycosphingolipid binding; growth factor activity; interleukin-2 receptor binding; interleukin-2 receptor binding; kappa-type opioid receptor binding; kinase activator activity