il2

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il2

Official Full Name interleukin 2
Background IL-2 is amember of a family of cytokines, which also includes IL-4, IL-7, IL-9, IL-15and IL-21. IL-2 signals through a receptor complex consisting of IL-2specific IL-2 receptor alpha (CD25), IL-2 receptor beta (CD122) and a commongamma chain (γc), which is shared by all members of this family of cytokines.Binding of IL-2 activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Aktsignaling modules.<br/>IL-2 isnormally produced by the body during an immune response. When environmentalsubstances (molecules or microbes) gain access to the body, these substancesare recognized as foreign by antigen receptors that are expressed on thesurface of lymphocytes. Antigen binding to the T cell receptor (TCR)stimulates the secretion of IL-2, and the expression of IL-2 receptors IL-2R.The IL-2/IL-2R interaction then stimulates the growth, differentiation andsurvival of antigen-selected cytotoxic T cells via the activation of theexpression of specific genes. As such, IL-2 is necessary for the developmentof T cell immunologic memory, one of the unique characteristics of the immunesystem, which depends upon the expansion of the number and function ofantigen-selected T cell clones.<br/>IL-2 isalso necessary during T cell development in the thymus for the maturation ofa unique subset of T cells that are termed regulatory T cells (Tregs). Afterexiting from the thymus, T-Regs function to prevent other T cells fromrecognizing and reacting against "self antigens", which couldresult in "autoimmunity". T-Regs do so by preventing the respondingcells from producing IL-2. Thus, IL-2 is required to discriminate betweenself and nonself, another one of the unique characteristics of the immunesystem.<br/>IL-2 hasbeen found to be similar to IL-15 in terms of function. Both cytokines areable to facilitate production of immunoglobulins made by B cells and inducethe differentiation and proliferation of natural killer cells. The primarydifferences between IL-2 and IL-15 are found in adaptive immune responses.For example, IL-2 participates in maintenance of T-Regs and reducesselfreactive T cells. On the other hand, IL-15 is necessary for maintaininghighly specific T cell responses by supporting survival of CD8 memory Tcells.
Synonyms IL-2; interleukin 2; TCGF; lymphokine; interleukin-2; aldesleukin; T cell growth factor; involved in regulation of T-cell clonal expansion; Il2; OTTMUSP00000007837; T-cell growth factor
    • Species :
    • Canine
    • Cattle
    • Chicken
    • Cotton Rat
    • Cynomolgus Monkey
    • Equine
    • Feline
    • Ferret
    • Horse
    • Human
    • Mouse
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Rhesus monkey
    • Source :
    • Barley Grain
    • CHO
    • COS
    • E.coli
    • HEK293
    • HEK293F
    • Hordeum Vulgare
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • NS1
    • Yeast
    • Tag :
    • Fc
    • His
    • GST
    • S
    • SUMO
    • Myc
    • T7
    • HQ
    • Met
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus Monkey IL2-22C Recombinant Cynomolgus Monkey IL-2 Protein Yeast N/A
    Human IL2-1118H Recombinant Human IL2 Protein (Ala21-Thr153), Biotinylated E.coli N/A
    Horse IL2-113E Recombinant Horse IL2 protein E.coli N/A
    Human IL2-311H Recombinant Human IL2 protein E.coli
    Canine IL2-445C Recombinant Canine IL2 Protein E.coli N/A
    Rat Il2-864R Recombinant Rat Il2 protein E.coli N/A
    Human diphtheria toxin&IL2-P031H Recombinant Human IL2/diphtheria toxin, His-tagged therapeutic protein E.coli His
    Human IL2-028E Recombinant Human IL2 (21-153aa), Met tagged E.coli N/A
    Human IL2-06H Recombinant Human IL2 protein E.coli N/A
    Human IL2-116H Recombinant Human Interleukin 2 HEK293 N/A
    Human IL2-134H Recombinant Human IL2 protein E.coli N/A
    Human IL2-152HG GMP Recombinant Human IL2 Protein HEK293 His
    Human IL2-167H Recombinant Human IL2, MIgG2a Fc-tagged CHO Fc
    Human IL2-169H Recombinant Human IL2, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL2-170H Recombinant Human IL2, HIgG1 Fc-tagged CHO Fc
    Human IL2-219H Recombinant Human IL2, StrepII-tagged Human Cell Strep II
    Human IL2-25H Recombinant Human IL2, His-tagged Barley Grain His
    Human IL2-2741H Recombinant Human IL2 Yeast N/A
    Human IL2-29H Recombinant Human IL2 protein Insect Cell N/A
    Human IL2-305H Recombinant Human IL2, Fc-tagged CHO Fc
    Human IL2-306H Recombinant Human IL2, Fc-tagged NS1 Fc
    Human IL2-341H Recombinant Human IL2 Human N/A
    Human IL2-376H Recombinant Human Interleukin-2, His-tagged Human HIS
    Human IL2-402H Recombinant Human Interleukin-2 His Tag Human His
    Human IL2-4317HG GMP Recombinant Human IL2 protein E.coli N/A
    Human IL2-464H Recombinant Human Interleukin 2 E.coli N/A
    Human IL2-473H Recombinant Human IL2 protein, His-tagged HEK293F His
    Human IL2-501H Recombinant Human IL2, His tagged Human Cell His
    Human IL2-502H Recombinant Human IL2 HEK293 N/A
    Human IL2-5234HCL Recombinant Human IL2 293 Cell Lysate HEK293 N/A
    Human IL2-636H Recombinant Human Interleukin 2, HQ-tagged Hordeum Vulgare HQ
    Human IL2-68H Recombinant Human IL-2 Yeast N/A
    Human IL2-741H Recombinant Human interleukin 2 E.coli N/A
    Human IL2-80H Human Interleukin- 2 (rDNA derived) Reference standard N/A
    Human IL2-8861H Recombinant Human Interleukin 2, His-tagged Hordeum Vulgare N/A
    Human IL2-P044H Recombinant Human IL2 therapeutic protein E.coli N/A
    Mouse Il2-106M Recombinant Mouse Il2 Protein E.coli N/A
    Mouse Il2-131M Mouse Interleukin-2 (rDNA derived) Reference standard N/A
    Mouse IL2-168H Recombinant Human il2, MIgG2a Fc-tagged, mutant NS1 Fc
    Mouse Il2-307M Recombinant Mouse Il2, Fc-tagged NS1 Fc
    Mouse Il2-308M Recombinant Mouse Il2, Fc-tagged CHO Fc
    Mouse IL2-333M Recombinant Mouse IL2, MIgG2a Fc-tagged CHO Fc
    Mouse IL2-403M Recombinant Mouse Interleukin-2, His Tag Mouse His
    Mouse Il2-465M Recombinant Mouse Interleukin 2 E.coli N/A
    Mouse Il2-553M Recombinant Mouse Il2 protein, His-tagged HEK293F His
    Mouse Il2-637M Recombinant Mouse Il2 protein, His & T7-tagged E.coli His/T7
    Mouse Il2-687M Recombinant Mouse Il2 protein E.coli N/A
    Mouse IL2-955M Recombinant Mouse IL2 Protein E.coli N/A
    Mouse ll2-538M Recombinant Mouse Interleukin 2, His-tagged Mouse N/A
    Rat IL2-3038R Recombinant Rat IL2 Protein Mammalian Cell His
    Rat Il2-479R Recombinant Rat Il2 protein, His-tagged HEK293F His
    Rat Il2-575R Recombinant Rat Il2 protein E.coli N/A
    Rat IL2-611R Recombinant Rat Interleukin 2, HIgG1 Fc-tagged CHO Fc
    Rat Il2-638R Recombinant Rat Il2 protein, His & GST-tagged E.coli His/GST
    Rat Il2-747R Recombinant Rat Il2, None tagged E.coli N/A
    Rat Il2-94P Recombinant Rat Interleukin 2 E.coli N/A
    Cynomolgus Monkey IL2-616C Recombinant Cynomolgus IL2 Protein, His-tagged Mammalian Cell His
    Rhesus monkey IL2-1256R Recombinant Rhesus monkey IL2 Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
    Rhesus Macaque IL2-2242R Recombinant Rhesus monkey IL2 Protein, His-tagged Mammalian Cell His
    Chicken IL2-249C Recombinant Chicken Interleukin 2 Yeast N/A
    Chicken IL2-5729C Recombinant Chicken IL2 Mammalian Cell His
    Chicken IL2-590C Recombinant Chicken IL2 COS N/A
    Chicken IL2-636C Recombinant Chicken IL2 protein, His & S-tagged E.coli His/S
    Rabbit IL2-699R Recombinant Rabbit IL2, Met-tagged E.coli Met
    Equine IL2-255E Recombinant Equine Interleukin 2 Yeast N/A
    Feline IL2-260F Recombinant Feline IL2 protein Yeast N/A
    Cotton Rat Il2-381C Recombinant Cotton Rat Il2, Met-tagged E.coli Met
    Ferret IL2-4317F Recombinant Ferret IL2 Protein Yeast N/A
    Pig IL2-600P Recombinant Pig IL2 protein E.coli N/A
    Cattle IL2-635C Recombinant Cattle IL2 protein, His & T7-tagged E.coli His/T7
    Equine IL2-672E Recombinant Equine IL2, Met-tagged E.coli Met
    Porcine IL2-83P Recombinant Porcine IL2 Protein E.coli N/A

    il2 involved in several pathways and played different roles in them. We selected most pathways il2 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with il2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction EDA2R; CSF2RA; LTBR; CCL18; CXCR6; Flt3l; AMH; IL20RB; CCL24; CXCL9
    PIK-Akt signaling pathway IBSP; PPP2R3C; SGK3; RAF1; TLR2; LPAR2; G6PC; PPP2R5B; IFNA5; RPS6KB1
    Jak-STAT signaling pathway GHR; IFNAR2; GM-CSF; PTPN2A; CSH2; IL3; LEPB; BCL2; GHRA; STAT3
    T cell receptor signaling pathway DBNLB; PPP3R2; PDCD1; DLG1; CD8B1; NCK2; CD247; CD28; MAP2K1; CD4
    Intestinal i MHC2DAB; IL6; HLA-DQA2; HLA-DRB4; HLA-DOA; CD80; AICDA; HLA-DMA; HLA-DPB1; IL-15RA
    ne network for IgA production BMA1; CCR9A; HLA-DRB5; CD40; IL15; IL15RA; HLA-DPA1; TGFB1; HLA-DRB1; HLA-DQA1
    Type I diabetes mellitus INS2; H2-AB1; HLA-F; LTA; PRF1; IL12A; HLA-DRB5; IFNG; HLA-DRB3; GZMB
    Chagas disease (American trypanosomiasis) MAPK8; SMAD2; MAPK9; GNAQ; IRAK4; CD3D; Fasl; PIK3R2; CD247; TRAF6
    Measles PIK3R3; OAS1B; IFNG; TBK1; FAS; IL2RA; EIF2AK3; CD3G; CCND1; CD46
    HTLV-I infection TNFRSF1A; ANAPC4; XIAP; GSK3B; PDGFRA; SLC2A1; RAN; SMAD4; SMAD3; POLD4
    Autoi H2-AB1; HLA-DOB; HLA-G; IFNA2; HLA-DMA; Il2; FAS; CD28; IFNA10; IFNA17
    ne thyroid disease CD28; IL4; HLA-DOA; HLA-DRB5; CD40LG; HLA-DRB3; IFNA1; IFNA21; HLA-DMA; Fasl
    Inflammatory bowel disease (IBD) IL13; IL23R; HLA-DOB; STAT3; HLA-DPB1; HLA-DRB4; Il2; GATA3; TLR5; TGFB1
    Allograft rejection HLA-DPA1; MICA; H2-Q10; IFNG; HLA-DRB1; HLA-DMA; HLA-DRB3; HLA-DRB4; H2-AB1; HLA-DQA1
    Graft-versus-host disease CD80; KIR2DL3; HLA-B; GZMB; KLRC1; HLA-DQA1; H2-Q10; H2-AA; HLA-DQA2; HLA-DRB1

    il2 has several biochemical functions, for example, carbohydrate binding, cytokine activity, glycosphingolipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by il2 itself. We selected most functions il2 had, and list some proteins which have the same functions with il2. You can find most of the proteins on our site.

    Function Related Protein
    carbohydrate binding FCER2; NOMO3; ZG16B; CDIPT; HBL4; Cd209g; LGALS1L1; KLRB1; GFPT2; FREM1
    cytokine activity IFNA5; IL3; FASLG; IL1A; IFNA21; SP100; NRG1; CMTM5; CTF1; WNT1
    glycosphingolipid binding LYN; LAMA1; LAMB1; SELL; SELP; LAMC1; Il2; Cel
    growth factor activity PROK1; FGF11A; AMBN; VEGFA; MACC1; MDKB; LEFTY1; CSF1; Pdgfa&amp;Pdgfb; FGF2
    interleukin-2 receptor binding Il2; IL21; GATA3; ECM1; TIMM50
    kappa-type opioid receptor binding Il2

    il2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with il2 here. Most of them are supplied by our site. Hope this information will be useful for your research of il2.

    Il2rg

    Monzani, PS; Guemra, S; et al. MAC-T Cells as a Tool to Evaluate Lentiviral Vector Construction Targeting Recombinant Protein Expression in Milk. ANIMAL BIOTECHNOLOGY 26:136-142(2015).
    Habibi, D; Shamsian, A; et al. Synthesis of pyranopyrazoles, benzopyrans, amino-2-chromenes and dihydropyrano[c]chromenes using ionic liquid with dual Bronsted acidic and Lewis basic sites. CHEMICAL PAPERS 69:586-595(2015).

    IL

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