IL2

  • Official Full Name

    interleukin 2

  • Background

    IL-2 is amember of a family of cytokines, which also includes IL-4, IL-7, IL-9, IL-15and IL-21. IL-2 signals through a receptor complex consisting of IL-2specific IL-2 receptor alpha (CD25), IL-2 receptor beta (CD122) and a commongamma chain (γc), which is shared by all members of this family of cytokines.Binding of IL-2 activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Aktsignaling modules.<br/>IL-2 isnormally produced by the body during an immune response. When environmentalsubstances (molecules or microbes) gain access to the body, these substancesare recognized as foreign by antigen receptors that are expressed on thesurface of lymphocytes. Antigen binding to the T cell receptor (TCR)stimulates the secretion of IL-2, and the expression of IL-2 receptors IL-2R.The IL-2/IL-2R interaction then stimulates the growth, differentiation andsurvival of antigen-selected cytotoxic T cells via the activation of theexpression of specific genes. As such, IL-2 is necessary for the developmentof T cell immunologic memory, one of the unique characteristics of the immunesystem, which depends upon the expansion of the number and function ofantigen-selected T cell clones.<br/>IL-2 isalso necessary during T cell development in the thymus for the maturation ofa unique subset of T cells that are termed regulatory T cells (Tregs). Afterexiting from the thymus, T-Regs function to prevent other T cells fromrecognizing and reacting against "self antigens", which couldresult in "autoimmunity". T-Regs do so by preventing the respondingcells from producing IL-2. Thus, IL-2 is required to discriminate betweenself and nonself, another one of the unique characteristics of the immunesystem.<br/>IL-2 hasbeen found to be similar to IL-15 in terms of function. Both cytokines areable to facilitate production of immunoglobulins made by B cells and inducethe differentiation and proliferation of natural killer cells. The primarydifferences between IL-2 and IL-15 are found in adaptive immune responses.For example, IL-2 participates in maintenance of T-Regs and reducesselfreactive T cells. On the other hand, IL-15 is necessary for maintaininghighly specific T cell responses by supporting survival of CD8 memory Tcells.
  • Synonyms

    IL-2; interleukin 2; TCGF; lymphokine; interleukin-2; aldesleukin; T cell growth factor; involved in regulation of T-cell clonal expansion; Il2; OTTMUSP00000007837; T-cell growth factor;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • GMP Proteins
    • Cell & Tissue Lysates
    • Therapeutic Proteins
    • Transfected Stable Cell Lines
    • Species :
    • Canine
    • Cattle
    • Chicken
    • Cotton Rat
    • Cynomolgus
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Feline
    • Ferret
    • Guinea pig
    • Horse
    • Human
    • Mouse
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Rhesus monkey
    • Source :
    • Barley Grain
    • CHO
    • COS
    • E. coli
    • E.coli
    • HEK293
    • HEK293 cells
    • HEK293F
    • HEK293T
    • Hordeum Vulgare
    • Human
    • Human Cell
    • Human cells
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • NS1
    • Plants
    • Yeast
    • Tag :
    • C
    • Myc
    • DDK
    • Fc
    • Avi
    • GST
    • His
    • HIS
    • His (Fc)
    • His(C
    • ter)
    • His|GST
    • His|S
    • His|SUMO|Myc
    • His|T7
    • Met
    • MYC
    • N/A
    • N
    • hFc
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Canine IL2-445C Recombinant Canine IL2 Protein E.coli N/A
    Canine IL2-154C Recombinant Canine IL2 Protein E.coli
    Cattle IL2-635C Recombinant Cattle IL2 protein, His & T7-tagged E.coli His/T7
    Chicken IL2-590C Recombinant Chicken IL2 COS N/A
    Chicken IL2-03C Recombinant Chicken IL2 Protein, Biotinylated Conjugated Yeast
    Chicken IL2-249C Recombinant Chicken Interleukin 2 Yeast N/A
    Chicken IL2-636C Recombinant Chicken IL2 protein, His & S-tagged E.coli His/S
    Chicken IL2-590C Recombinant Chicken IL2 COS N/A
    Chicken IL2-5729C Recombinant Chicken IL2 Mammalian Cell His
    Cotton Rat Il2-381C Active Recombinant Cotton Rat Il2, Met-tagged E.coli Met
    Cynomolgus IL2-0181C Recombinant Cynomolgus IL2 protein, His-tagged HEK293 His
    Cynomolgus IL2-53C Recombinant Cynomolgus IL2 Protein, His-tagged HEK293 His
    Cynomolgus Monkey IL2-616C Recombinant Cynomolgus IL2 Protein, His-tagged Mammalian Cell His
    Cynomolgus Monkey IL2-363C Recombinant Cynomolgus Monkey IL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Cynomolgus Monkey IL2-363C-B Recombinant Cynomolgus Monkey IL2 Protein Pre-coupled Magnetic Beads HEK293
    Cynomolgus Monkey IL2-22C Recombinant Cynomolgus Monkey IL-2 Protein Yeast N/A
    Dog IL2-1023D Recombinant Dog IL2 Protein, His-tagged E.coli N-His
    Equine IL2-672E Active Recombinant Equine IL2, Met-tagged E.coli Met
    Equine IL2-255E Active Recombinant Equine Interleukin 2 Yeast N/A
    Feline IL2-260F Recombinant Feline IL2 protein Yeast N/A
    Ferret IL2-4317F Recombinant Ferret IL2 Protein Yeast N/A
    Guinea pig Il2-1024G Recombinant Guinea pig Il2 Protein, His-tagged E.coli N-His
    Horse IL2-113E Recombinant Horse IL2 protein E.coli N/A
    Horse IL2-1025H Recombinant Horse IL2 Protein, His-tagged E.coli N-His
    Human IL2-341H Active Recombinant Human IL2 Human N/A
    Human IL2-2741H Active Recombinant Human IL2 Yeast N/A
    Human IL2-1026H Recombinant Human IL2 Protein, His-tagged E.coli N-His
    Human IL2-01H Recombinant Human IL2 Protein (aa 21-153), N-Fc-tagged CHO N-hFc
    Human IL2-501H Active Recombinant Human IL2, His tagged Human Cell His
    Human IL2-68H Recombinant Human IL-2 Yeast N/A
    Human IL2-02HG Recombinant Human IL2 Protein (Ala21-Thr153), GMP Grade, Animal-Free E.coli
    Human IL2-248I Recombinant Human IL2 Protein CHO
    Human IL2-25H Active Recombinant Human IL2, His-tagged Barley Grain His
    Human IL2-028E Active Recombinant Human IL2 (21-153aa), Met tagged E.coli N/A
    Human IL2-27HG Recombinant Human IL2 Protein (Ala21-Thr153, Cys145Ser), GMP Grade, Animal-Free E.coli
    Human IL2-0182H Recombinant Human IL2 protein, Fc-tagged HEK293 Fc
    Human IL2-116H Active Recombinant Human Interleukin 2 HEK293 N/A
    Human IL2-5234HCL Recombinant Human IL2 293 Cell Lysate HEK293 N/A
    Human IL2-155H Recombinant Human IL2 Protein E.coli
    Human IL2-0184H Recombinant Human IL2 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi
    Human IL2-06H Recombinant Human IL2 Protein E.coli
    Human IL2-8861H Active Recombinant Human Interleukin 2, His-tagged Hordeum Vulgare N/A
    Human IL2-98H Recombinant Human IL2 Protein E.coli
    Human IL2-511H Recombinant Human IL2 Protein
    Human IL2-402H Recombinant Human Interleukin-2 His Tag Human His
    Human IL2-636H Recombinant Human IL2 Protein, His-tagged Plants His
    Human IL2-02H Recombinant Human IL2 Protein (Ala21-Thr153), Biotinylated E.coli
    Human IL2-311H Recombinant Human IL2 protein E.coli
    Human IL2-618H Recombinant Human IL2 protein, His-tagged E. coli His
    Human IL2-29H Active Recombinant Human IL2 protein Insect Cell N/A
    Human IL2-1118H Recombinant Human IL2 Protein (Ala21-Thr153), Biotinylated E.coli N/A
    Human IL2-4317HG GMP Recombinant Human IL2 protein E.coli N/A
    Human diphtheria toxin&IL2-P031H Recombinant Human IL2/diphtheria toxin, His-tagged therapeutic protein E.coli His
    Human IL2-473H Recombinant Human IL2 protein, His-tagged HEK293F His
    Human IL2-349H Recombinant Human IL2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human IL2-153HG GMP Recombinant Human IL-2 protein CHO
    Human IL2-152HG GMP Recombinant Human IL2 Protein HEK293
    Human IL2-150HGB GMP Recombinant Human IL2 Protein E. coli
    Human IL2-064H Recombinant Human IL2 Protein E. coli
    Human IL2-41H Recombinant Human IL2 Protein E.coli
    Human IL2-5446H Recombinant Human IL2 protein, His-tagged Yeast His
    Human IL2-474H Recombinant Human IL2(Ala21-Thr153) Protein, C-6*His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human IL2-3099H Recombinant Human IL2 protein, GST-tagged E.coli GST
    Human IL2-306H Active Recombinant Human IL2, Fc-tagged NS1 Fc
    Human IL2-01HG Recombinant Human IL2 Protein (Ala21-Thr153), GMP Grade, Animal-Free E.coli
    Human IL2-150HG Active GMP Recombinant Human IL2 protein E.coli N/A
    Human IL2-134H Active Recombinant Human IL2 protein E.coli N/A
    Human IL2-169H Active Recombinant Active Human IL2 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human IL2-30H Recombinant Human IL2 Protein, Animal Free Human cells
    Human IL2-167H Active Recombinant Human IL2, MIgG2a Fc-tagged CHO Fc
    Human IL2-80H Human Interleukin- 2 (rDNA derived) Reference standard N/A
    Human IL2-219H Recombinant Human IL2, StrepII-tagged Human Cell Strep II
    Human IL2-0016H Recombinant Human IL2 Protein HEK293 cells
    Human IL2-464H Active Recombinant Human Interleukin 2 E.coli N/A
    Human IL2-502H Recombinant Human IL2 protein HEK293 N/A
    Human IL2-305H Recombinant Human IL2, Fc-tagged CHO Fc
    Human IL2-170H Active Recombinant Human IL2, HIgG1 Fc-tagged CHO Fc
    Human IL2-741H Active Recombinant Human interleukin 2 E.coli N/A
    Human IL2-P044H Recombinant Human IL2 therapeutic protein E.coli N/A
    Human IL2-376H Recombinant Human Interleukin-2, His-tagged Human HIS
    Human IL2-30HG Recombinant Human IL2 Protein, GMP Grade, Animal-Free E.coli
    Human IL2-07H Recombinant Human IL2 Protein, Pre-aliquoted E.coli
    Mouse Il2-7239M Recombinant Mouse Il2 Protein, His-tagged E.coli His
    Mouse Il2-028I Recombinant Mouse Il2 Protein (149 aa) E.coli
    Mouse Il2-307M Active Recombinant Mouse Il2, Fc-tagged NS1 Fc
    Mouse IL2-0183M Recombinant Mouse IL2 protein, His-tagged HEK293 His
    Mouse IL2-955M Active Recombinant Mouse IL2 Protein E.coli N/A
    Mouse IL2-79M Recombinant Mouse IL2 Protein E.coli
    Mouse Il2-465M Active Recombinant Mouse Interleukin 2 E.coli N/A
    Mouse Il2-687M Recombinant Mouse Il2 protein E.coli N/A
    Mouse Il2-637M Recombinant Mouse Il2 protein, His & T7-tagged E.coli His/T7
    Mouse Il2-170M Recombinant Active Mouse IL2 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Il2-104M Recombinant Mouse Il2 Protein E.coli
    Mouse Il2-308M Recombinant Mouse Il2, Fc-tagged CHO Fc
    Mouse IL2-403M Active Recombinant Mouse Interleukin-2, His Tag Mouse His
    Mouse IL2-333M Active Recombinant Mouse IL2, MIgG2a Fc-tagged CHO Fc
    Mouse IL2-156M Recombinant Mouse IL2 Protein E.coli
    Mouse Il2-106M Recombinant Mouse Il2 Protein E.coli N/A
    Mouse ll2-538M Recombinant Mouse Interleukin 2, His-tagged Mouse N/A
    Mouse IL2-168H Active Recombinant Human il2, MIgG2a Fc-tagged, mutant NS1 Fc
    Mouse Il2-131M Mouse Interleukin-2 (rDNA derived) Reference standard N/A
    Mouse Il2-105M Recombinant Mouse Il2 Protein E.coli
    Mouse Il2-107M Recombinant Mouse Il2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Il2-553M Recombinant Mouse Il2 protein, His-tagged HEK293F His
    Mouse Il2-01M Active Recombinant Mouse Il2 Protein, His-Tagged E.coli His
    Pig IL2-600P Recombinant Pig IL2 protein E.coli N/A
    Pig IL2-1027P Recombinant Pig IL2 Protein, His-tagged E.coli N-His
    Pig IL2-171P Recombinant Active Pig IL2 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Porcine IL2-83P Active Recombinant Porcine IL2 Protein E.coli N/A
    Porcine IL2-157P Recombinant Porcine IL2 Protein E.coli
    Porcine IL2-158P Recombinant Porcine IL2 Protein E.coli
    Porcine IL2-01P Active GMP Recombinant Porcine IL2 Protein, His-Tagged E.coli His
    Rabbit IL2-3100R Recombinant Rabbit IL2 protein, His-tagged E.coli His
    Rabbit IL2-02R Recombinant Rabbit IL2 Protein Yeast
    Rabbit IL2-699R Active Recombinant Rabbit IL2, Met-tagged E.coli Met
    Rabbit IL2-5447R Recombinant Rabbit IL2 protein, His-tagged Yeast His
    Rat Il2-94P Recombinant Rat Interleukin 2 E.coli N/A
    Rat IL2-2693R Recombinant Rat IL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat Il2-747R Recombinant Rat Il2, None tagged E.coli N/A
    Rat IL2-3038R Recombinant Rat IL2 Protein Mammalian Cell His
    Rat Il2-638R Recombinant Rat Il2 protein, His & GST-tagged E.coli His/GST
    Rat Il2-480R Recombinant Rat Il2 Protein, His-tagged HEK293 His
    Rat Il2-864R Recombinant Rat Il2 protein E.coli N/A
    Rat IL2-159R Recombinant Rat IL2 Protein E.coli
    Rat Il2-575R Recombinant Rat Il2 protein E.coli N/A
    Rat IL2-611R Active Recombinant Rat Interleukin 2, HIgG1 Fc-tagged CHO Fc
    Rat Il2-479R Recombinant Rat Il2 protein, His-tagged HEK293F His
    Rat IL2-2693R-B Recombinant Rat IL2 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque IL2-2242R Recombinant Rhesus monkey IL2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque IL2-2063R-B Recombinant Rhesus Macaque IL2 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque IL2-2063R Recombinant Rhesus Macaque IL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus monkey IL2-1256R Recombinant Rhesus monkey IL2 Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL2 Related Articles
    • IL2 Related Gene Family
    • IL2 Related Research Area
    • IL2 Related Signal Pathway

    IL2 involved in several pathways and played different roles in them. We selected most pathways IL2 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionIL1RAP;CX3CR1;TNFSF8;PDGFB;CCR1;KITLGB;FLT3LG;CCR3;CCL23
    PIK-Akt signaling pathwayCOL6A6;PTEN;TSC2;FGF9;ITGA4;PPP2R1A;FGF21;RPS6KB2;GH2
    Jak-STAT signaling pathwayGRB2B;LEPR;AOX3;IL29;IL20RB;IL6ST;EPOR;CRFB2;IFNK
    T cell receptor signaling pathwayDLG1;MUC1;NFKBIA;PTPRC;SLA1;CD8B;MAPK11;IKBKG;PPP3CA
    Intestinal iITGB7;IL-15RA;TGFB1A;MADCAM1;CD40LG;BMA2;MHC2DCB;HLA-DRB1;TNFRSF17
    ne network for IgA productionHLA-DMA;CCL27B;BLB2;TNFRSF13B;PIGR;BMA2;BLA;HLA-DRB4;HLA-DRA
    Type I diabetes mellitusHLA-DPA1;CD80;HLA-G;IL12B;HLA-DQA2;HLA-B;HLA-DPB1;FASLG;HLA-DMB
    Chagas disease (American trypanosomiasis)SERPINE1;TNFRSF1A;GNAL;IL10;Fasl;MAPK8;BDKRB2;Il2;TGFBR1
    MeaslesEIF2AK4;cgr2b;IL12A;TBK1;IFNA16;IFNB1;GSK3B;DOK1;EIF2AK1
    HTLV-I infectionTBP;TGFBR1;VDAC2;WNT8B;HLA-B;WNT4;FZD9;LCK;ELK4
    AutoiIFNA7;H2-AA;IFNA17;IL4;IFNA4;TSHB;HLA-DRB5;IFNA1;TPO
    ne thyroid diseaseHLA-DMB;HLA-DRB1;IFNA12;IFNA7;TSHR;IFNA21;IFNA10;HLA-B;H2-Q10
    Inflammatory bowel disease (IBD)RORC;IL13;SMAD3;IL22;IL21R;TNF;IL12A;TGFB2;TLR5
    Allograft rejectionFasl;GZMB;MICA;HLA-DOA;H2-AB1;CD28;H2-Q10;HLA-DQB1;IL10
    Graft-versus-host diseaseHLA-DRA;HLA-C;HLA-DMA;KLRC1;CD28;HLA-DRB4;IL1B;HLA-DQA2;IL1A

    IL2 has several biochemical functions, for example, carbohydrate binding, cytokine activity, glycosphingolipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL2 itself. We selected most functions IL2 had, and list some proteins which have the same functions with IL2. You can find most of the proteins on our site.

    Function Related Protein
    carbohydrate bindingLPHN1;CHODL;Clec4n;CD34;EVA1C;ZG16B;CLEC2H;CNTN2;MRC2
    cytokine activityIL17F;NDR1;NDP;THPO;TNFSF13;GDF1;GM13288;OSM;IL12BA
    glycosphingolipid bindingIl2;LYN;SELP;LAMA1;LAMC1;LAMB1;SELL;Cel
    growth factor activityBTC;BMP15;CXCL12;JAG2;VEGFA;INHBAA;INHBA;CSPG5;IL9
    interleukin-2 receptor bindingIL21;TIMM50;ECM1;GATA3;Il2
    kappa-type opioid receptor binding

    IL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL2.

    Il2rg

    Monzani, PS; Guemra, S; et al. MAC-T Cells as a Tool to Evaluate Lentiviral Vector Construction Targeting Recombinant Protein Expression in Milk. ANIMAL BIOTECHNOLOGY 26:136-142(2015).
    Habibi, D; Shamsian, A; et al. Synthesis of pyranopyrazoles, benzopyrans, amino-2-chromenes and dihydropyrano[c]chromenes using ionic liquid with dual Bronsted acidic and Lewis basic sites. CHEMICAL PAPERS 69:586-595(2015).
    IL
    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    What is the impact of IL2 on T-cell memory formation? 04/25/2022

    IL2 promotes the formation of memory T-cells.

    What is the role of IL2 in the tumor microenvironment? 12/12/2021

    IL2 has a pro-tumorigenic role in the tumor microenvironment.

    How does IL2 interact with other cytokines in a mixed environment? 11/22/2021

    IL2 synergizes with IL-12 in a mixed cytokine environment.

    Does IL2 modulate the expression of checkpoint inhibitors? 06/03/2020

    IL2 upregulates the expression of PD-1 checkpoint inhibitors.

    What are the kinetics of IL2 internalization in T cells? 08/18/2019

    IL2 is rapidly internalized by activated T-cells.

    Does IL2 influence the polarization of macrophages? 07/24/2019

    IL2 induces M1 macrophage polarization.

    How does IL2 affect the blood-brain barrier permeability? 07/06/2018

    IL2 increases blood-brain barrier permeability.

    How does IL2's affinity for its receptor change under hypoxic conditions? 04/11/2018

    IL2's affinity for its receptor decreases under hypoxic conditions.

    What post-translational modifications affect IL2's bioactivity? 02/19/2017

    IL2's bioactivity is enhanced by glycosylation.

    What is the role of IL2 in the differentiation of Th17 cells? 04/20/2016

    IL2 promotes the differentiation of Th17 cells.

    Customer Reviews (3)

    Write a review
    Reviews
    04/13/2022

      Potent in T-cell activation. -

      07/27/2018

        Suitable for cytokine assays. -

        01/07/2018

          High stability. -

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