Human IDO2 Inhibitor Screening Assay Kit
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Cat.No. : | Kit-1759 |
Product Overview : | L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp and releasing degradation products of L-Trp that have immunosuppressive functions. Indoleamine 2,3- dioxygenases (IDO1 & IDO2), two of the rate limiting enzymes in this pathway, are upregulated in many tumors, providing cancer cells with an avenue for immune evasion. |
Size : | 96 reactions |
Applications : | Useful for the study of IDO2 enzymology, screening inhibitors, and selectivity profiling. |
Storage : | At least 6 months from date of receipt when stored as directed. |
◆ Recombinant Protein
Ido2-3475M | Recombinant Mouse Ido2 Protein, Myc/DDK-tagged | +Inquiry |
IDO2-1420H | Recombinant Human IDO2 Protein (14-420 aa), His-tagged | +Inquiry |
Ido2-1176M | Recombinant Mouse Ido2 protein, His-tagged | +Inquiry |
IDO2-23H | Recombinant Human IDO2 protein, MYC/DDK-tagged | +Inquiry |
IDO2-22H | Recombinant Human IDO2 protein, His-tagged | +Inquiry |
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◆ Lysates
IDO2-5299HCL | Recombinant Human IDO2 293 Cell Lysate | +Inquiry |
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◆ Assay kits
Kit-1783 | Mouse IDO2 Inhibitor Screening Assay Kit | +Inquiry |
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