Human TDO Fluorogenic Inhibitor Screening Assay Kit
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|Product Overview :||L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp and releasing degradation products of L-Trp that have immunosuppressive functions., Tryptophan 2,3 dioxygenase (TDO) a rate limiting enzymes in this pathway, is upregulated in many tumors, providing cancer cells with an avenue for immune evasion.|
|Size :||96 reactions|
|Applications :||Useful for the study of TDO enzymology, inhibitor screening, and selectivity profiling.|
|Storage :||Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.|