PARPtrap Assay Kit
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|Product Overview :||PARP1 is known to bind damaged DNA through its N-terminal zinc finger domain. After PARP1 ribosylates itself (autoribosylation), it dissociates from DNA due to the accumulated negative charge of the ribosyl polymer. Trapped PARP-DNA complexes have been shown to be cytotoxic to cancer cells.|
|Size :||96 reactions|
|Applications :||Great for screening small molecules that enhance PARP1/DNA trapping for drug discovery and HTS applications.|
|Storage :||Up to 1 year when stored as recommended.|