PCSK9-LDLR in vitro Binding Assay Kit
Cat.No. : | Kit-0666 |
Product Overview : | The PCSK9-LDLR in vitro Binding Assay Kit is primarily designed to screening inhibitors of PCSK9-LDLR interaction in vitro. In addition, this kit can be used for the rapid and sensitive evaluation of inhibitor candidates as well as characterization of PCSK9-LDLR interaction in vitro. The recombinant LDLR-EGF-AB domain used in this assay kit was specially designed for keeping the correct conformation to bind PCSK9, even if immobilized on the microplate surface. This technique allows us measuring efficiently the interaction of recombinant PCSK9 to recombinant LDLR-AB domain in a solid-phase assay system such as a conventional ELISA system. |
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Size : | 96 assay |
Applications : | 1) Screening inhibitors of PCSK9-LDLR interaction in vitro.2) Characterization of inhibitor candidates of PCSK9-LDLR interaction in vitro.3) Screening monoclonal antibody that inhibits PCSK9-LDLR interaction in vitro.4) Characterization of PCSK9-LDLR interaction in vitro. |
Storage : | Upon receipt, store all other components at 4°C;Don"t expose reagents to excessive light.All of the reagents included in the CycLex Research Product CircuLex PCSK9-LDLR in vitro Binding Assay Kit have been tested for stability. Reagents should not be used beyond the stated expiration date. |
Products Types
◆ Recombinant Protein | ||
Pcsk9-209M | Active Recombinant Mouse Pcsk9 Protein, His-Avi-tagged, Biotinylated | +Inquiry |
PCSK9-413R | Recombinant Rat PCSK9 Protein, His-tagged | +Inquiry |
PCSK9-312H | Recombinant Human PCSK9 protein(Met1-Gln692), His-tagged | +Inquiry |
PCSK9-1622H | Recombinant Human PCSK9 Protein, His (Fc)-Avi-tagged | +Inquiry |
PCSK9-352H | Active Recombinant Human PCSK9 Protein, His & Avi-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
PCSK9-2775RCL | Recombinant Rhesus PCSK9 cell lysate | +Inquiry |
PCSK9-2564MCL | Recombinant Mouse PCSK9 cell lysate | +Inquiry |
PCSK9-2306RCL | Recombinant Rat PCSK9 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1806 | PCSK9(D374T)-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-1808 | PCSK9-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-1807 | PCSK9[Biotinylated]-LDLR Binding Assay Kit | +Inquiry |
Kit-0665 | PCSK9-BIRC2 in vitro Binding Assay Kit | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIn immunological experiments, it was found that it had good antigenicity and could induce target immune responses.
It promoted cell growth and proliferation.
High catalytic efficiency.
Q&As (6)
Ask a questionYes, some studies suggest that mutations in the PCSK9 protein gene may increase the risk of cardiovascular disease. For example, some PCSK9 mutations can cause their dysfunction, resulting in hypercholesterolemia and cardiovascular disease.
PCSK9 protein is combined with immune adjuvants to make a vaccine, or mutated PCSK9 protein to induce an immune response to it, inhibit PCSK9 expression in vivo, increase LDLR levels and reduce serum cholesterol levels.
This protein may have a regulatory effect on weight and obesity, and it is associated with glucose and endocannabinin homeostasis studies have linked PCSK9 to the development of obesity and diabetes.
Several new anti-PCSK9 drugs are already being studied and developed, including oral drugs and gene chromosome therapies, and some drugs have advanced to early stages of clinical trials, providing new options for the treatment of PCSK9 proteins.
Currently on the market to inhibit PCSK9 protein drugs include alirocumab and evolocumab.
PCSK9 protein can degrade LDLR protein, so its overexpression will lead to a decrease in LDLR's ability to be cleared, leading to hypercholesterolemia.
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