PCSK9-LDLR in vitro Binding Assay Kit

Cat.No. : Kit-0666
Product Overview : The PCSK9-LDLR in vitro Binding Assay Kit is primarily designed to screening inhibitors of PCSK9-LDLR interaction in vitro. In addition, this kit can be used for the rapid and sensitive evaluation of inhibitor candidates as well as characterization of PCSK9-LDLR interaction in vitro. The recombinant LDLR-EGF-AB domain used in this assay kit was specially designed for keeping the correct conformation to bind PCSK9, even if immobilized on the microplate surface. This technique allows us measuring efficiently the interaction of recombinant PCSK9 to recombinant LDLR-AB domain in a solid-phase assay system such as a conventional ELISA system.
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Size : 96 assay
Applications : 1) Screening inhibitors of PCSK9-LDLR interaction in vitro.2) Characterization of inhibitor candidates of PCSK9-LDLR interaction in vitro.3) Screening monoclonal antibody that inhibits PCSK9-LDLR interaction in vitro.4) Characterization of PCSK9-LDLR interaction in vitro.
Storage : Upon receipt, store all other components at 4°C;Don"t expose reagents to excessive light.All of the reagents included in the CycLex Research Product CircuLex PCSK9-LDLR in vitro Binding Assay Kit have been tested for stability. Reagents should not be used beyond the stated expiration date.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (6)

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Is there a relationship between genetic mutations in the PCSK9 protein and cardiovascular disease? 12/30/2019

Yes, some studies suggest that mutations in the PCSK9 protein gene may increase the risk of cardiovascular disease. For example, some PCSK9 mutations can cause their dysfunction, resulting in hypercholesterolemia and cardiovascular disease.

How can PCSK9 protein be used for vaccine development? 12/17/2019

PCSK9 protein is combined with immune adjuvants to make a vaccine, or mutated PCSK9 protein to induce an immune response to it, inhibit PCSK9 expression in vivo, increase LDLR levels and reduce serum cholesterol levels.

What is the relationship between PCSK9 protein and obesity? 07/23/2019

This protein may have a regulatory effect on weight and obesity, and it is associated with glucose and endocannabinin homeostasis studies have linked PCSK9 to the development of obesity and diabetes.

What are the new prospects for future therapies that inhibit PCSK9 protein? 06/26/2019

Several new anti-PCSK9 drugs are already being studied and developed, including oral drugs and gene chromosome therapies, and some drugs have advanced to early stages of clinical trials, providing new options for the treatment of PCSK9 proteins.

What drugs are currently available to inhibit the PCSK9 protein? 05/08/2019

Currently on the market to inhibit PCSK9 protein drugs include alirocumab and evolocumab.

What is the relationship between PCSK9 protein and hypercholesterolemia? 01/11/2019

PCSK9 protein can degrade LDLR protein, so its overexpression will lead to a decrease in LDLR's ability to be cleared, leading to hypercholesterolemia.

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    In immunological experiments, it was found that it had good antigenicity and could induce target immune responses.


      It promoted cell growth and proliferation.


        High catalytic efficiency.

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