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Recombinant Active Human IL36B Protein, His-tagged(C-ter)

Cat.No. : IL36B-197H
Product Overview : Recombinant Active Human IL36B Protein with His tag (C-ter) was expressed in E. coli.
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  • Gene Information
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Description : The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Source : E. coli
Species : Human
Tag : His(C-ter)
Form : Powder
Bio-activity : Determined by its ability to induce IL-8 secretion in human PBMCs. The ED50 for this effect is < 0.2 ng/mL.
AA Sequence : MREAAPKSYAIRDSRQMVWVLSGNS LIAAPLSRSIKPVTLHLIACRDTEF SDKEKGNMVYLGIKGKDLCLFCAEI QGKPTLQLKEKNIMDLYVEKKAQKP FLFFHNKEGSTSVFQSVSYPGWFIA TSTTSGQPIFLTKERGITNNTNFYL DSVE
Endotoxin : Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.
Purity : > 98% (by SDS-PAGE)
Applications : SDS-PAGE
Notes : For laboratory research only, not for drug, diagnostic or other use.
Storage : Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
Storage Buffer : PBS (pH 7.4)
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.
Gene Name : IL36B interleukin 36, beta [ Homo sapiens ]
Official Symbol : IL36B
Synonyms : IL36B; interleukin 36, beta; IL1F8, interleukin 1 family, member 8 (eta); interleukin-36 beta; FIL1; FILI (ETA); IL 1F8; IL 1H2; IL1 ETA; IL1H2; MGC126880; MGC126882; FIL1 eta; IL-1 eta; IL-1F8 (FIL1-eta); interleukin-1 eta; interleukin 1, eta; interleukin-1 homolog 2; Interleukin-1 Superfamily e; family of interleukin 1-eta; interleukin-1 family member 8; IL1F8 (Canonical product IL-1F8a); interleukin 1 family, member 8 (eta); FIL1H; IL1F8; IL-1F8; IL-1H2; IL1-ETA; FIL1-(ETA); FILI-(ETA);
Gene ID : 27177
mRNA Refseq : NM_014438
Protein Refseq : NP_055253
MIM : 605508
UniProt ID : Q9NZH7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the research topics related to IL36B? 06/28/2022

Research topics related to IL36B include in-depth study of its signal transduction mechanism, evaluation of therapeutic efficacy, and comparison with other therapeutic approaches.

What is the action mechanism of IL36B? 04/08/2022

IL36B exerts its therapeutic role by binding to its receptors, activating signaling pathways and regulating inflammatory and immune responses.

How long does the effect of IL36B last? 09/07/2021

The duration of the IL36B's efficacy will vary from individual to individual, and regular treatment is usually required to maintain the effect.

Are there other treatments similar to IL36B? 09/17/2020

Yes, there are other treatments similar to IL36B, such as antibody drugs and small molecule compounds.

How to determine the dosage and frequency of IL36B? 12/03/2019

The dosage and frequency of use are determined according to the specific circumstances of the patient and the results of the clinical trial, and are usually adjusted on an individual basis based on the clinical trial.

How was the IL36B developed and used in production? 05/16/2019

The development process of IL36B includes basic research, drug screening, clinical trials and other stages, and has been developed after long-term efforts

Customer Reviews (3)

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Reviews
10/11/2022

    When conducting experiments with IL36B, it is easy to operate and does not require complex operating steps.

    03/09/2022

      The stability of IL36B has good adaptability under different temperature and pH conditions.

      10/16/2021

        The structure of IL36B was validated with no abnormal protein folding or inactivation.

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