Recombinant Bacillus subtilis ALAT protein, His-tagged

• Cat.No.: ALAT-2534B
• Product Overview: Recombinant Bacillus subtilis ALAT full length or partial length protein was expressed.

Specification

• Source: E. coli or Yeast
• Species: Bacillus subtilis
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: > 80% by SDS-PAGE
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
• Storage buffer: PBS buffer

Gene Information

• Gene Name: alaT aminotransferase YugH [ Bacillus subtilis subsp. subtilis str. 168 ]
• Official Symbol: ALAT
• Synonyms: ALAT; aminotransferase YugH
• Gene ID: 938846
• UniProt ID: Q795M6

Reviews

05/31/2021

The combination of the protein's exceptional characteristics and the manufacturer's outstanding technical assistance equips me with the necessary resources to overcome potential hurdles and achieve groundbreaking results.

07/09/2016

Its impressive purity and functional properties make it an ideal choice for my research, ensuring precise and accurate results.

06/09/2016

Their expertise and responsiveness exemplify their dedication to assisting customers, offering solutions and guidance whenever challenges arise.

Q&As

What are the normal range values for ALAT levels?

The normal range values for ALAT (also known as ALT) levels can vary slightly between different laboratories, but generally, they are below 45 units per liter (U/L) for men and below 34 U/L for women. It is important to note that these values may differ depending on the reference range used by the specific laboratory conducting the test. Consulting with a healthcare professional can help provide accurate interpretation of ALAT levels based on individual circumstances.

Are there any medications that can cause elevated ALAT levels?

Yes, certain medications can cause elevated ALAT levels as a side effect. These include some antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), statins, antiepileptic drugs, and anti-tuberculosis medications, among others. If you suspect that a medication you are taking may be causing elevated ALAT levels, it is important to discuss this with your healthcare provider. They may suggest alternative medications or adjust the dosage to minimize liver side effects.

Can ALAT levels be used to monitor the progression of liver disease?

ALAT levels can be used as one of the markers to monitor the progression of liver disease. Regular monitoring of ALAT levels can help healthcare professionals assess the response to treatment, disease progression, or the effectiveness of lifestyle modifications. However, it is important to note that ALAT levels may fluctuate and other liver function tests, imaging studies, and clinical evaluation are also necessary to get a comprehensive picture of liver health.

What causes elevated ALAT levels in the blood?

Elevated ALAT levels in the blood may occur due to liver damage, inflammation, or disease. Conditions such as viral hepatitis, alcohol abuse, non-alcoholic fatty liver disease (NAFLD), drug-induced liver injury, and liver cancer can cause increased ALAT levels. However, it is important to note that ALAT elevation alone does not provide a specific diagnosis, and further testing is required to determine the underlying cause.

How long does it take for ALAT levels to return to normal after liver injury?

The time it takes for ALAT levels to return to normal after liver injury can vary depending on the extent and cause of the injury. In cases of acute liver injury, such as drug-induced liver injury or acute viral hepatitis, ALAT levels typically start to decrease within a few weeks. However, in chronic liver diseases like cirrhosis, it may take much longer for ALAT levels to stabilize or normalize, and some liver damage may be irreversible.

Is there a relationship between ALAT and ASAT (AST) levels?

Both ALAT and ASAT (also known as AST) are enzymes involved in amino acid metabolism. While ALAT is primarily found in the liver, ASAT is present in various organs including the liver, heart, muscle, and other tissues. An elevation in both ALAT and ASAT levels can indicate liver damage or disease. The ratio of ALAT to ASAT levels may be useful in determining the underlying cause and severity of liver injury.

Is high ALAT levels always indicative of liver disease?

While elevated ALAT levels are commonly associated with liver disease, it is not always the sole indicator. ALAT is primarily found in the liver, but it is also present in other organs like the heart, kidneys, and muscles. Certain non-liver-related conditions, such as muscle injury, strenuous exercise, and certain medications, can also lead to increased ALAT levels in the blood.

Can dietary factors affect ALAT levels?

Some dietary factors may indirectly impact ALAT levels. For example, excessive alcohol consumption can lead to liver damage and elevated ALAT levels. A healthy, balanced diet that includes fruits, vegetables, whole grains, lean proteins, and limited processed foods may support liver health and help maintain normal ALAT levels. However, modifying diet alone may not significantly affect ALAT levels if there is an underlying liver condition.

What are the common causes of elevated ALAT levels?

Elevated ALAT levels can be caused by various factors including liver diseases such as hepatitis (both viral and alcoholic), fatty liver disease, cirrhosis, liver cancer, and drug-induced liver injury. Other factors that can lead to elevated ALAT levels include excessive alcohol consumption, certain medications, obesity, diabetes, and autoimmune hepatitis. Further investigation and diagnostic tests may be required to determine the specific cause of elevated ALAT levels.

How are ALAT levels measured?

ALAT levels can be measured through a simple blood test. A healthcare provider will collect a blood sample, and the laboratory will analyze the sample to determine the amount of ALAT present. Normal ranges may vary between laboratories, but typically, normal ALAT levels are considered to be below 40 units per liter (U/L) for men and 30 U/L for women.

Can stress or physical activity affect ALAT levels?

Stress and physical activity can have temporary effects on ALAT levels. Acute physical activity, such as intense exercise, may cause a temporary increase in ALAT levels, but they usually return to normal within a few days. Additionally, stress can also elevate ALAT levels in some individuals. However, if ALAT levels remain consistently elevated, it is essential to consider other potential causes and seek medical evaluation.

Are there any natural remedies or dietary changes that can help lower ALAT levels?

While there are no specific natural remedies or dietary changes proven to lower ALAT levels, adopting a healthy lifestyle can support liver health. This includes consuming a balanced diet rich in fruits, vegetables, whole grains, and lean proteins. Avoiding processed foods, high-fat foods, and excessive alcohol consumption can also be beneficial.

How can ALAT levels be lowered?

Lowering ALAT levels depends on the underlying cause of elevated levels. If the elevation is due to lifestyle factors such as excessive alcohol consumption or obesity, making lifestyle changes can help. This includes reducing alcohol intake, maintaining a healthy weight through diet and exercise, and avoiding hepatotoxic substances. If the elevation is due to a specific liver disease, treatment options will vary.

Can exercise affect ALAT levels?

Intense physical activity or strenuous exercise can temporarily increase ALAT levels. This is known as exercise-induced liver injury. The elevation in ALAT levels is usually mild and transient, returning to normal within a few days. Regular exercise is generally beneficial for overall health, but individuals with underlying liver conditions should consult with a healthcare professional about appropriate exercise routines.

Are there any medications that can lower ALAT levels?

There are no specific medications designed to directly lower ALAT levels. However, medications may be prescribed to treat the underlying condition causing elevated ALAT levels, such as antiviral medications for viral hepatitis or medications for liver inflammation. It is important to consult with a healthcare professional for appropriate treatment options based on the underlying cause.

What are the symptoms of high ALAT levels?

High ALAT levels themselves do not typically cause specific symptoms. However, if the underlying cause of elevated ALAT levels is liver disease, symptoms may include fatigue, abdominal pain, loss of appetite, nausea, jaundice (yellowing of the skin and eyes), dark urine, and pale stools. It is important to identify and address the underlying cause of high ALAT levels to manage any associated symptoms.

Can lifestyle changes help in reducing elevated ALAT levels?

In some cases, lifestyle changes can help reduce elevated ALAT levels. For example, individuals with fatty liver disease may be advised to make dietary modifications, lose weight, engage in regular exercise, and limit alcohol consumption. However, the specific approach to managing elevated ALAT levels will depend on the underlying cause, and it's important to consult with a healthcare professional for personalized guidance.

Can ALAT levels fluctuate throughout the day?

ALAT levels can vary throughout the day, but the fluctuations are generally not significant unless there is an underlying liver condition. It is common for laboratory results to show slight variations in ALAT levels between different blood samples. The most accurate assessment of ALAT levels is typically obtained through multiple blood tests over a period of time.

Can ALAT levels be used to diagnose liver disease?

Elevated ALAT levels alone are not sufficient to diagnose a specific liver disease. They are an indicator of liver damage or injury, but further tests, medical history evaluation, and physical examination are necessary to determine the underlying cause. Additional liver function tests, imaging studies, and potentially liver biopsy may be required to confirm a diagnosis and develop an appropriate treatment plan.