| Cat.No. : |
CTLA4-2073P |
| Product Overview : |
Purified CTLA4 (AAH74842.1, 37 a.a. - 161 a.a.) human recombinant protein with His-Flag-StrepII tag at N-terminus expressed in human cells. |
| Description : |
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008] |
| Source : |
Human cells |
| Species : |
Human |
| Tag : |
His-Flag-StrepII |
| Form : |
Liquid |
| Bio-activity : |
Not Tested |
| Molecular Mass : |
19.03 kDa |
| AA Sequence : |
AMHVAQPAVV LASSRGIASF VCEYASPGKA TEVRVTVLRQ ADSQVTEVCA ATYMMGNELT FLDDSICTGT SSGNQVNLTI QGLRAMDTGL YICKVELMYP PPYYLGIGNG TQIYVIDPEP CPDSD |
| Applications : |
Western Blot
Enzyme-linked Immunoabsorbent Assay
SDS-PAGE
Protein Interaction |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Concentration : |
≥ 10 μg/ml |
| Storage Buffer : |
100 mM Tris-HCl pH 8.0, 150 mM NaCl, 1 mM EDTA, and 5 mM desthiobiotin. |
| Quality Control Testing: : |
SDS-PAGE Gel
|
| Western Blot : |
|
