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Recombinant CTLA4 Protein, His-Flag-StrepII-tagged

Cat.No. : CTLA4-2073P
Product Overview : Purified CTLA4 (AAH74842.1, 37 a.a. - 161 a.a.) human recombinant protein with His-Flag-StrepII tag at N-terminus expressed in human cells.
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Description : This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Source : Human cells
Species : Human
Tag : His-Flag-StrepII
Form : Liquid
Bio-activity : Not Tested
Molecular Mass : 19.03 kDa
AA Sequence : AMHVAQPAVVLASSRGIASFVCEYA SPGKATEVRVTVLRQADSQVTEVCA ATYMMGNELTFLDDSICTGTSSGNQ VNLTIQGLRAMDTGLYICKVELMYP PPYYLGIGNGTQIYVIDPEPCPDSD
Applications : Western Blot
Enzyme-linked Immunoabsorbent Assay
SDS-PAGE
Protein Interaction
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Concentration : ≥ 10 μg/ml
Storage Buffer : 100 mM Tris-HCl pH 8.0, 150 mM NaCl, 1 mM EDTA, and 5 mM desthiobiotin.
Gene Name : CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens ]
Official Symbol : CTLA4
Synonyms : CTLA4; cytotoxic T-lymphocyte-associated protein 4; celiac disease 3 , CELIAC3; cytotoxic T-lymphocyte protein 4; CD; CD28; CD152; GSE; ICOS; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; GRD4; CTLA-4; IDDM12; CELIAC3;
Gene ID : 1493
mRNA Refseq : NM_001037631
Protein Refseq : NP_001032720
MIM : 123890
UniProt ID : P16410

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there ongoing clinical trials exploring CTLA-4 inhibitors in combination with other immunotherapies? 05/16/2020

Yes, several clinical trials are investigating the combination of CTLA-4 inhibitors with PD-1 inhibitors and other immunotherapies to improve the overall effectiveness of cancer treatment.

How does the expression of CTLA-4 vary in different types of immune cells? 10/17/2019

CTLA-4 is expressed on various immune cells, including T cells, regulatory T cells (Tregs), and some B cells, contributing to its diverse immunoregulatory functions.

In what ways can CTLA-4 be utilized in organ transplantation? 01/11/2017

Modulating CTLA-4 may have applications in organ transplantation by suppressing the immune response against transplanted tissues and reducing the risk of rejection.

How does CTLA-4 contribute to the maintenance of immune tolerance? 04/30/2016

CTLA-4 is involved in the suppression of autoreactive T cells, contributing to the prevention of autoimmune responses by maintaining immune tolerance.

How does CTLA-4 blockade differ from PD-1/PD-L1 blockade in cancer immunotherapy? 03/18/2016

While both CTLA-4 and PD-1/PD-L1 inhibitors enhance anti-tumor immune responses, they target different checkpoints in the immune system. CTLA-4 primarily regulates T-cell activation in the early stages, whereas PD-1/PD-L1 acts later in the immune response.

Customer Reviews (3)

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Reviews
04/17/2019

    It has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.

    11/25/2018

      The CTLA4 protein is a top-quality product that is sure to fulfill my experimental requirements.

      01/28/2017

        the ease of use and compatibility of the CTLA4 protein with various techniques further enhances its appeal.

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