Recombinant Full Length Human AGXT, Flag-tagged

Cat.No. : AGXT-6061HFL
Product Overview : Recombinant Full Length Human AGXT, fused with C-terminal Flag tag, was expressed in mamanlian cells.
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Source : Mamanlian cells
Species : Human
Tag : Flag
Molecular Mass : 42.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Storage : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Concentration : >50 ug/mL as determined by microplate BCA method
Shipping : The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Gene Name : AGXT alanine-glyoxylate aminotransferase [ Homo sapiens (human) ]
Official Symbol : AGXT
Synonyms : AGXT; AGT; PH1; SPT; AGT1; SPAT; TLH6; AGXT1; alanine-glyoxylate aminotransferase; serine--pyruvate aminotransferase; serine-pyruvate aminotransferase; serine:pyruvate aminotransferase; alanine--glyoxylate aminotransferase; L-alanine: glyoxylate aminotransferase 1; hepatic peroxisomal alanine:glyoxylate aminotransferase; NP_000021.1; EC; EC
Gene ID : 189
mRNA Refseq : NM_000030
Protein Refseq : NP_000021
MIM : 604285
UniProt ID : P21549

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (10)

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Are there any known structural motifs in AGXT essential for its enzymatic activity? 02/28/2022

AGXT contains a PLP-binding domain, characteristic of aminotransferases, which is critical for its enzymatic activity and substrate specificity.

Can mutations in the AGXT gene lead to any hereditary disorders? 06/04/2021

Yes, mutations in the AGXT gene can cause primary hyperoxaluria type 1 (PH1), a rare autosomal recessive disorder characterized by the overproduction and accumulation of oxalate, resulting in severe kidney and urinary tract complications.

Can AGXT be targeted therapeutically for the treatment of kidney stones in non-PH1 patients? 01/07/2021

Targeting AGXT enzymatic activity may hold promise for developing therapies to prevent kidney stone formation in non-PH1 patients; however, further research is needed to validate this approach.

Which cellular compartment is AGXT predominantly localized in? 12/30/2020

AGXT is primarily localized in the peroxisomes, a subcellular organelle responsible for various metabolic processes, including lipid metabolism and detoxification.

Can AGXT activity be influenced by epigenetic modifications? 10/28/2020

Epigenetic modifications, such as DNA methylation or histone acetylation, could potentially regulate AGXT gene expression and activity, affecting oxalate metabolism.

How is AGXT activity regulated at the post-translational level? 03/15/2020

AGXT activity can be regulated by phosphorylation, allosteric modulation, and interaction with other proteins involved in peroxisomal metabolism.

What is the primary function of AGXT in the human body? 08/17/2019

AGXT plays a crucial role in the peroxisomal glyoxylate pathway, converting glyoxylate to glycine to prevent the accumulation of harmful oxalate, which can lead to kidney stone formation.

How does AGXT deficiency lead to hyperoxaluria in PH1 patients? 05/23/2019

In PH1 patients, AGXT deficiency impairs the conversion of glyoxylate to glycine, leading to the accumulation of glyoxylate. Excessive glyoxylate is converted to oxalate, which can form kidney stones and cause tissue damage.

Is AGXT involved in other physiological processes beyond oxalate metabolism? 12/19/2018

AGXT may participate in other cellular processes or metabolic pathways, and its broader functional roles warrant further exploration.

What is the reaction catalyzed by AGXT in the glyoxylate pathway? 11/10/2018

AGXT catalyzes the conversion of glyoxylate and L-alanine to glycine and pyruvate, utilizing PLP as a cofactor.

Customer Reviews (5)

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