Recombinant Full Length Human APOBEC3A protein, Flag-tagged

Cat.No. : APOBEC3A-5726HFL
Product Overview : Recombinant Full Length Human APOBEC3A protein, fused with C-terminal Flag tag, was expressed in mamanlian cells.
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Source : Mamanlian cells
Species : Human
Tag : Flag
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 23 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Shipping : The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Gene Name : APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A [ Homo sapiens ]
Official Symbol : APOBEC3A
Synonyms : A3A; ARP3; PHRBN; bK150C2.1; phorbolin 1; phorbolin-1; probable DNA dC->dU-editing enzyme APOBEC-3A
Gene ID : 200315
mRNA Refseq : NM_145699
Protein Refseq : NP_663745
MIM : 607109
UniProt ID : P31941

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (18)

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Are there any known genetic variants or polymorphisms of the APOBEC3A gene? 03/27/2023

Yes, genetic variants and polymorphisms of the APOBEC3A gene have been identified. These variations can affect the protein's activity or expression levels, potentially influencing its role in antiviral defense and mutagenesis.

Will this work in a Western blot? 03/07/2023

Yes, our APOBEC3A proteins can be used in Western Blot.

Is APOBEC3A solely involved in antiviral defense, or does it have other cellular functions? 01/29/2023

Although APOBEC3A is primarily recognized for its antiviral activities, recent studies suggest it may play additional roles. It has been implicated in DNA repair processes, regulation of immune responses, and potential contributions to autoimmune disorders.

Can APOBEC3A inhibitors be developed as antiviral drugs? 06/10/2022

Given the anti-viral activity of APOBEC3A, there is interest in developing inhibitors that can block its function to limit viral replication. However, the development of specific and potent inhibitors is complex due to the structural similarities and overlapping functions of other APOBEC3 proteins.

Can alterations or mutations in the APOBEC3A gene lead to any genetic disorders or diseases? 05/14/2022

While dysregulation of APOBEC3A activity has been implicated in cancer development, there is currently limited evidence linking alterations or mutations in the APOBEC3A gene to specific genetic disorders or diseases.

Are there any known cellular inhibitors or regulators of APOBEC3A activity? 08/29/2021

Several cellular factors, such as APOBEC3B, have been shown to interact with APOBEC3A and regulate its activity. Additionally, post-translational modifications, such as phosphorylation, may also modulate its function.

Are there any known viral inhibitors of APOBEC3A? 07/24/2021

Several viruses have evolved strategies to counteract or evade the antiviral activity of APOBEC3A. For example, human immunodeficiency virus type 1 (HIV-1) encodes the protein Vif, which targets APOBEC3A (and other APOBEC3 proteins) for degradation.

What are the potential consequences of APOBEC3A-induced DNA mutations? 07/18/2021

APOBEC3A-induced DNA mutations can have diverse outcomes. On one hand, they can inhibit viral replication by introducing hypermutations that lead to non-functional viral genomes. On the other hand, excessive APOBEC3A activity or dysregulated expression can contribute to genomic instability and promote cancer development.

Does APOBEC3A have any interactions with other cellular proteins or pathways? 06/22/2021

APOBEC3A has been reported to interact with several cellular proteins involved in DNA repair, immune responses, and viral pathogenesis. These interactions contribute to the regulation of its activity, but the full extent and functional consequences of these interactions are still being explored.

Does APOBEC3A play a role in the evolution of viruses? 08/18/2019

Yes, APOBEC3A-induced hypermutation can accelerate the evolution of various viruses, particularly RNA viruses. By introducing errors in viral genomes during replication, APOBEC3A can drive the emergence of viral variants that can potentially escape host immune responses or develop drug resistance.

Is APOBEC3A expressed in all cell types or tissues? 12/11/2018

APOBEC3A expression can vary among different cell types and tissues. It is predominantly expressed in tissues exposed to viral infections, such as the gastrointestinal tract, reproductive organs, and lymphoid tissues.

What other APOBEC3 proteins are closely related to APOBEC3A? 10/12/2018

APOBEC3A belongs to a family of seven APOBEC3 proteins in humans, including APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H. These proteins share similar structural features and exhibit overlapping antiviral functions.

Can APOBEC3A be targeted for therapeutic purposes? 06/12/2018

The antiviral and mutagenic activities of APOBEC3A make it an attractive target for therapeutic interventions. However, due to its potential for causing DNA mutations and genomic instability, careful consideration is needed to balance the benefits and potential risks in therapeutic applications.

Can APOBEC3A deaminate cytosine in both RNA and DNA molecules? 03/25/2018

No, APOBEC3A is primarily known for its activity on DNA molecules. It catalyzes the deamination of cytosines in single-stranded DNA, which can lead to the generation of uracil and subsequent DNA mutations.

Can APOBEC3A activity be modulated by environmental factors? 08/29/2017

There is evidence suggesting that certain environmental factors, such as chronic viral infections or exposure to genotoxic agents like cigarette smoke, can stimulate APOBEC3A expression and activity. These factors may contribute to increased DNA damage and mutagenesis.

Are there any therapeutic strategies targeting APOBEC3A for cancer treatment? 03/28/2017

While direct targeting of APOBEC3A for cancer treatment is challenging due to its mutagenic properties, there are ongoing efforts to develop therapeutic approaches that modulate its expression or activity to balance its antiviral effects while minimizing genomic instability.

Can APOBEC3A be used as a diagnostic or prognostic marker for cancer? 03/14/2016

The increased expression and mutational activity of APOBEC3A in certain cancers have led to investigations into its potential diagnostic and prognostic value. However, further research is needed to establish its utility as a clinical marker.

Are there any known diseases or conditions associated with APOBEC3A dysregulation? 02/08/2016

Dysregulation of APOBEC3A has been implicated in cancer development, specifically in various types of malignancies, including breast, cervical, and head and neck cancers. Elevated APOBEC3A expression and activity have been associated with increased mutagenesis and tumor evolution.

Customer Reviews (4)

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Reviews
10/31/2018

    the APOBEC3A protein has proven to be invaluable in protein electron microscopy structure analysis.

    09/04/2017

      I must applaud the APOBEC3A protein for its outstanding performance in Western blotting experiments.

      03/07/2017

        I highly recommend the APOBEC3A protein for a variety of experimental applications.

        03/03/2017

          The remarkable quality and reliability of the APOBEC3A protein have significantly contributed to the success of my structural investigations.

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