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Active Recombinant Full Length Human USP20 Protein, C-Flag-tagged

Cat.No. : USP20-787HFL
Product Overview : Recombinant Full Length Human USP20 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
  • Specification
  • Gene Information
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Description : This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Bio-activity : Pull-down assay
Molecular Mass : 101.7 kDa
AA Sequence : MGDSRDLCPHLDSIGEVTKEDLLLK SKGTCQSCGVTGPNLWACLQVACPY VGCGESFADHSTIHAQAKKH NLTVNLTTFRLWCYACEKEVFLEQR LAAPLLGSSSKFSEQDSPPPSHPLK AVPIAVADEGESESEDDDLK PRGLTGMKNLGNSCYMNAALQALSN CPPLTQFFLECGGLVRTDKKPALCK SYQKLVSEVWHKKRPSYVVP TSLSHGIKLVNPMFRGYAQQDTQEF LRCLMDQLHEELKEPVVATVALTEA RDSDSSDTDEKREGDRSPSE DEFLSCDSSSDRGEGDGQGRGGGSS QAETELLIPDEAGRAISEKERMKDR KFSWGQQRTNSEQVDEDADV DTAMAALDQPAEAQPPSPRSSSPCR TPEPDNDAHLRSSSRPCSPVHHHEG HAKLSSSPPRASPVRMAPSY VLKKAQVLSAGSRRRKEQRYRSVIS DIFDGSILSLVQCLTCDRVSTTVET FQDLSLPIPGKEDLAKLHSA IYQNVPAKPGACGDSYAAQGWLAFI VEYIRRFVVSCTPSWFWGPVVTLED CLAAFFAADELKGDNMYSCE RCKKLRNGVKYCKVLRLPEILCIHL KRFRHEVMYSFKINSHVSFPLEGLD LRPFLAKECTSQITTYDLLS VICHHGTAGSGHYIAYCQNVINGQW YEFDDQYVTEVHETVVQNAEGYVLF YRKSSEEAMRERQQVVSLAA MREPSLLRFYVSREWLNKFNTFAEP GPITNQTFLCSHGGIPPHKYHYIDD LVVILPQNVWEHLYNRFGGG PAVNHLYVCSICQVEIEALAKRRRI EIDTFIKLNKAFQAEESPGVIYCIS MQWFREWEAFVKGKDNEPPG PIDNSRIAQVKGSGHVQLKQGADYG QISEETWTYLNSLYGGGPEIAIRQS VAQPLGPENLHGEQKIEAET
RAVTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome, Protease
Gene Name : USP20 ubiquitin specific peptidase 20 [ Homo sapiens (human) ]
Official Symbol : USP20
Synonyms : VDU2; hVDU2; LSFR3A
Gene ID : 10868
mRNA Refseq : NM_006676.8
Protein Refseq : NP_006667.3
MIM : 615143
UniProt ID : Q9Y2K6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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