Recombinant Full Length Human XIAP Protein, C-Flag-tagged
Cat.No. : | XIAP-1757HFL |
Product Overview : | Recombinant Full Length Human XIAP Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 56.5 kDa |
AA Sequence : | MTFNSFEGSKTCVPADINKEEEFVE EFNRLKTFANFPSGSPVSASTLARA GFLYTGEGDTVRCFSCHAAV DRWQYGDSAVGRHRKVSPNCRFING FYLENSATQSTNSGIQNGQYKVENY LGSRDHFALDRPSETHADYL LRTGQVVDISDTIYPRNPAMYSEEA RLKSFQNWPDYAHLTPRELASAGLY YTGIGDQVQCFCCGGKLKNW EPCDRAWSEHRRHFPNCFFVLGRNL NIRSESDAVSSDRNFPNSTNLPRNP SMADYEARIFTFGTWIYSVN KEQLARAGFYALGEGDKVKCFHCGG GLTDWKPSEDPWEQHAKWYPGCKYL LEQKGQEYINNIHLTHSLEE CLVRTTEKTPSLTRRIDDTIFQNPM VQEAIRMGFSFKDIKKIMEEKIQIS GSNYKSLEVLVADLVNAQKD SMQDESSQTSLQKEISTEEQLRRLQ EEKLCKICMDRNIAIVFVPCGHLVT CKQCAEAVDKCPMCYTVITF KQKIFMSTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome |
Protein Pathways : | Apoptosis, Focal adhesion, NOD-like receptor signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis |
Gene Name : | XIAP X-linked inhibitor of apoptosis [ Homo sapiens (human) ] |
Official Symbol : | XIAP |
Synonyms : | API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3 |
Gene ID : | 331 |
mRNA Refseq : | NM_001167.4 |
Protein Refseq : | NP_001158.2 |
MIM : | 300079 |
UniProt ID : | P98170 |
Products Types
◆ Recombinant Protein | ||
XIAP-399H | Recombinant Human XIAP Protein, MYC/DDK-tagged | +Inquiry |
XIAP-2365H | Recombinant Human XIAP Protein, His (Fc)-Avi-tagged | +Inquiry |
XIAP-2873H | Recombinant Human Full length XIAP protein(1-497 aa), C-His-tagged | +Inquiry |
XIAP-0712H | Recombinant Human XIAP Protein (Y120-P260), GST tagged | +Inquiry |
XIAP-0711H | Recombinant Human XIAP Protein (Y120-P260), Tag Free | +Inquiry |
◆ Lysates | ||
XIAP-263HCL | Recombinant Human XIAP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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