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Recombinant Human ACTN2 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : ACTN2-5633H
Product Overview : ACTN2 MS Standard C13 and N15-labeled recombinant protein (NP_001094) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 103.7 kDa
AA Sequence : MNQIEPGVQYNYVYDEDEYMIQEEE WDRDLLLDPAWEKQQRKTFTAWCNS HLRKAGTQIENIEEDFRNGLKLMLL LEVISGERLPKPDRGKMRFHKIANV NKALDYIASKGVKLVSIGAEEIVDG NVKMTLGMIWTIILRFAIQDISVEE TSAKEGLLLWCQRKTAPYRNVNIQN FHTSWKDGLGLCALIHRHRPDLIDY SKLNKDDPIGNINLAMEIAEKHLDI PKMLDAEDIVNTPKPDERAIMTYVS CFYHAFAGAEQAETAANRICKVLAV NQENERLMEEYERLASELLEWIRRT IPWLENRTPEKTMQAMQKKLEDFRD YRRKHKPPKVQEKCQLEINFNTLQT KLRISNRPAFMPSEGKMVSDIAGAW QRLEQAEKGYEEWLLNEIRRLERLE HLAEKFRQKASTHETWAYGKEQILL QKDYESASLTEVRALLRKHEAFESD LAAHQDRVEQIAAIAQELNELDYHD AVNVNDRCQKICDQWDRLGTLTQKR REALERMEKLLETIDQLHLEFAKRA APFNNWMEGAMEDLQDMFIVHSIEE IQSLITAHEQFKATLPEADGERQSI MAIQNEVEKVIQSYNIRISSSNPYS TVTMDELRTKWDKVKQLVPIRDQSL QEELARQHANERLRRQFAAQANAIG PWIQNKMEEIARSSIQITGALEDQM NQLKQYEHNIINYKNNIDKLEGDHQ LIQEALVFDNKHTNYTMEHIRVGWE LLLTTIARTINEVETQILTRDAKGI TQEQMNEFRASFNHFDRRKNGLMDH EDFRACLISMGYDLGEAEFARIMTL VDPNGQGTVTFQSFIDFMTRETADT DTAEQVIASFRILASDKPYILAEEL RRELPPDQAQYCIKRMPAYSGPGSV PGALDYAAFSSALYGESDLTRTRPL EQKLISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : ACTN2 actinin alpha 2 [ Homo sapiens (human) ]
Official Symbol : ACTN2
Synonyms : ACTN2; actinin, alpha 2; alpha-actinin-2; F-actin cross-linking protein; alpha-actinin skeletal muscle; CMD1AA;
Gene ID : 88
mRNA Refseq : NM_001103
Protein Refseq : NP_001094
MIM : 102573
UniProt ID : P35609

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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