Recombinant Human AIM2 Protein (S144-T343), His tagged

Species :	Human
Source :	E.coli
Tag :	His
Protein Length :	S144-T343
Description :	Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precursor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Form :	Liquid
Endotoxin :	< 0.01 EU per μg of the protein
Purity :	90%
Stability :	Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Storage :	Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles
Storage Buffer :	Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Shipping :	It is shipped out with blue ice.

Gene Name	AIM2 absent in melanoma 2 [ Homo sapiens (human) ]
Official Symbol	AIM2
Synonyms	AIM2; absent in melanoma 2; interferon-inducible protein AIM2; PYHIN4;
Gene ID	9447
mRNA Refseq	NM_004833
Protein Refseq	NP_004824
MIM	604578
UniProt ID	O14862