Recombinant Human AIM2 Protein (S144-T343), His tagged

• Cat.No.: AIM2-0587H
• Product Overview: Recombinant Human 6His-MBP-TEV-GG-AIM2(S144-T343 end) Protein was expressed in E. coli.

Specification

• Description: Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precursor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: S144-T343
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: AIM2 absent in melanoma 2 [ Homo sapiens (human) ]
• Official Symbol: AIM2
• Synonyms: AIM2; absent in melanoma 2; interferon-inducible protein AIM2; PYHIN4
• Gene ID: 9447
• mRNA Refseq: NM_004833
• Protein Refseq: NP_004824
• MIM: 604578
• UniProt ID: O14862