Recombinant Human AKR7A3, His-tagged

Cat.No. : AKR7A3-26727TH
Product Overview : Recombinant full length Human AKR7A3 with a N terminal His tag. 370 amino acids with a predicted MWt 41.6 kDa including tag.
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Description : Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.
Protein length : 331 amino acids
Conjugation : HIS
Molecular Weight : 41.600kDa inclusive of tags
Source : E. coli
Tissue specificity : Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.
Biological activity : Specific activity: approximately
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : pH: 8.00Constituents:0.32% Tris HCl, 0.58% Sodium chloride, 10% Glycerol
Storage : Please see Notes section
Sequences of amino acids : MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSELEM SRQLSRARPA TVLGAMEMGR RMDAPTSAAV TRAFLERGHT EIDTAFVYSE GQSETILGGL GLRLGGSDCR VKIDTKAIPL FGNSLKPDSL RFQLETSLKR LQCPRVDLFY LHMPDHSTPV EETLRACHQL HQEGKFVELG LSNYAAWEVA EICTLCKSNG WILPTVYQGM YNAITRQVET ELFPCLRHFG LRFYAFNPLA GGLLTGKYKY EDKDGKQPVG RFFGNTWAEM YRNRYWKEHH FEGIALVEKA LQAAYGASAP SMTSATLRWM YHHSQLQGAH GDAVILGMSS LEQLEQNLAA AEEGPLEPAV VDAFNQAWHL VAHECPNYFR
Sequence Similarities : Belongs to the aldo/keto reductase 2 family.
Gene Name : AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) [ Homo sapiens ]
Official Symbol : AKR7A3
Synonyms : AKR7A3; aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase); aflatoxin B1 aldehyde reductase member 3;
Gene ID : 22977
mRNA Refseq : NM_012067
Protein Refseq : NP_036199
MIM : 608477
Uniprot ID : O95154
Chromosome Location : 1p36.13
Pathway : Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P450, conserved biosystem;
Function : aldo-keto reductase (NADP) activity; electron carrier activity; oxidoreductase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (22)

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Are there any known inhibitors or drugs that target AKR7A3? 02/11/2023

Although there is limited information on specific inhibitors or drugs that target AKR7A3, some studies have reported the potential inhibitory effects of certain chemical compounds on AKR7A3 activity. For example, a study found that the chemical compound procyanidin B2 inhibited AKR7A3 in vitro, suggesting that it could potentially modulate aflatoxin metabolism. However, further research is needed to determine the effectiveness and specificity of these compounds as AKR7A3 inhibitors.

How is the expression of AKR7A3 regulated? 06/14/2022

The regulation of AKR7A3 expression is not yet fully understood. However, studies suggest that it can be influenced by various factors, including transcription factors, epigenetic modifications, and signaling pathways involved in response to aflatoxin exposure or oxidative stress. Further research is needed to elucidate the regulatory mechanisms of AKR7A3 expression.

Where is the AKR7A3 protein primarily expressed? 02/01/2022

The AKR7A3 protein is primarily expressed in the liver, which is the main site of aflatoxin metabolism.

Can AKR7A3 be used as a biomarker for aflatoxin exposure or liver cancer risk? 10/03/2021

There is ongoing research investigating the potential use of AKR7A3 as a biomarker for aflatoxin exposure and liver cancer risk. Changes in AKR7A3 expression or activity may be indicative of aflatoxin exposure or an individual's susceptibility to aflatoxin-induced liver cancer. However, more studies are needed to establish its reliability and clinical application as a biomarker.

Can AKR7A3 polymorphisms affect drug metabolism? 09/28/2021

AKR7A3 polymorphisms may potentially affect drug metabolism due to its role in detoxification pathways. However, the specific impact of AKR7A3 polymorphisms on drug metabolism is not yet well-established. Further studies and clinical research are required to determine whether AKR7A3 polymorphisms can influence drug metabolism and potentially impact individual responses to medications.

Are there any known drugs or therapies targeting AKR7A3 for the treatment of liver diseases? 01/28/2021

Currently, there are no specific drugs or therapies targeting AKR7A3 for the treatment of liver diseases. However, understanding its role in aflatoxin metabolism and liver carcinogenesis may help in the development of potential therapeutic strategies in the future.

How does AKR7A3 protect against aflatoxin-induced liver damage? 01/15/2021

AKR7A3 protects against aflatoxin-induced liver damage by catalyzing the reduction of aflatoxin aldehydes into less harmful metabolites. This enzymatic activity decreases the levels of reactive and toxic metabolites, reducing their potential for damaging DNA and causing liver injury or cancer.

Is AKR7A3 expression associated with prognosis or survival in liver cancer patients? 08/15/2020

Limited studies have suggested that decreased expression of AKR7A3 may be associated with poorer prognosis or survival in certain liver cancer cases. However, more comprehensive studies are required to establish a clear association between AKR7A3 expression and liver cancer prognosis.

How is AKR7A3 activity measured or quantified? 03/08/2020

AKR7A3 activity can be measured or quantified by assessing its enzymatic function, specifically its ability to reduce aflatoxin aldehydes. This can be done using techniques such as enzyme activity assays, biochemical assays, or mass spectrometry-based methods. These methods allow researchers to determine the catalytic activity of AKR7A3 and evaluate its role in aflatoxin metabolism.

Can AKR7A3 expression be modulated or enhanced to improve aflatoxin detoxification? 04/07/2019

There is currently limited knowledge regarding the modulation or enhancement of AKR7A3 expression to improve aflatoxin detoxification. However, strategies that aim to enhance AKR7A3 activity or expression, such as identifying chemical compounds or dietary factors that can upregulate AKR7A3, could potentially be explored for improving aflatoxin detoxification in the future.

Is AKR7A3 expression influenced by dietary factors? 03/04/2019

Dietary factors, including the consumption of aflatoxin-contaminated food, can impact AKR7A3 expression. Chronic exposure to aflatoxins can lead to increased expression of AKR7A3 as a protective response against aflatoxin-induced liver damage. However, the exact relationship between dietary factors and AKR7A3 expression requires further investigation.

Are there any genetic variations or polymorphisms in the AKR7A3 gene? 01/27/2019

Yes, genetic variations and polymorphisms have been identified in the AKR7A3 gene. Some of these variations may impact the activity or expression of the AKR7A3 protein, potentially affecting an individual's susceptibility to aflatoxin-induced liver damage and cancer.

Are there any genetic diseases associated with mutations in the AKR7A3 gene? 12/16/2018

As of now, no genetic diseases have been directly linked to mutations in the AKR7A3 gene. However, given its role in aflatoxin metabolism, it is possible that genetic variations in AKR7A3 may impact an individual's susceptibility to aflatoxin-related diseases, such as liver cancer. Further research is warranted to explore this possibility.

Can the AKR7A3 protein be used as a target for the development of anti-aflatoxin treatments? 10/06/2018

As AKR7A3 plays a role in the detoxification of aflatoxin aldehydes, it could potentially be targeted for the development of anti-aflatoxin treatments. However, the complexity of aflatoxin metabolism and the need for specificity in targeting AKR7A3 make this a challenging task. Future research may explore the potential of AKR7A3 as a therapeutic target.

Are there any known diseases or conditions associated with dysfunctions in the AKR7A3 protein? 06/29/2018

While no specific diseases or conditions have been directly linked to AKR7A3 dysfunction, alterations in aflatoxin metabolism influenced by AKR7A3 can contribute to the development of liver diseases, including hepatocellular carcinoma (HCC). However, the exact role of AKR7A3 in these diseases and its potential therapeutic implications require further investigation.

Does AKR7A3 have any other known functions besides aflatoxin metabolism? 05/13/2018

Currently, the primary known function of AKR7A3 is its involvement in the metabolism of aflatoxins. However, further research is needed to determine if it has additional roles or functions.

Are there any known inhibitors or inducers of AKR7A3 activity? 02/28/2018

Currently, there are no well-established inhibitors or inducers of AKR7A3 activity. Investigations into modulators of AKR7A3 are limited, and further research is needed to identify compounds that can modulate its activity.

Are there any genetic variations or mutations in the AKR7A3 gene that can affect its function? 09/07/2017

Several genetic variations and mutations have been identified in the AKR7A3 gene that can potentially affect its function. These variations can alter the structure or activity of the AKR7A3 protein, leading to differences in aflatoxin metabolism and potential susceptibility to aflatoxin-related diseases. However, the specific effects of these variations on AKR7A3 function and their clinical implications require further investigation.

Can AKR7A3 be targeted for therapeutic interventions? 11/02/2016

Although targeting AKR7A3 for therapeutic interventions is still an area of ongoing research, its involvement in aflatoxin detoxification and potential roles in other processes makes it an intriguing target. Modulating AKR7A3 activity or expression could potentially be explored for the prevention or treatment of diseases related to aflatoxin exposure. However, more studies are needed to validate this approach and determine its feasibility in clinical settings.

Are there any known diseases or disorders associated with AKR7A3 mutations? 07/10/2016

There are no known diseases or disorders directly associated with AKR7A3 mutations. However, variations in AKR7A3 have been studied in the context of aflatoxin-related diseases, such as hepatocellular carcinoma (liver cancer) and other liver diseases. Further studies are necessary to determine the potential link between AKR7A3 mutations and the development or progression of specific diseases or disorders.

Is AKR7A3 expressed in tissues other than the liver? 07/09/2016

Yes, AKR7A3 is expressed in various tissues other than the liver. It has been detected in the kidney, lung, small intestine, colon, esophagus, bladder, and prostate, among others. The broad expression pattern of AKR7A3 indicates that it may play a role in detoxification processes and protection against toxic compounds in multiple organs.

Can AKR7A3 be used as a biomarker for aflatoxin exposure or liver disease? 04/20/2016

While AKR7A3 expression has been investigated as a potential biomarker for aflatoxin exposure and liver disease, its clinical utility as a stand-alone biomarker is still uncertain. Further research is needed to determine the specificity and sensitivity of AKR7A3 as a biomarker in different populations and disease settings.

Customer Reviews (4)

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Reviews
03/06/2021

    Its stability and reliability warrant its inclusion in my research protocols, leading to meaningful and conclusive results.

    01/09/2020

      Their prompt and effective responses help ensure smooth and efficient progress, indeed solving any problem that arises.

      05/27/2019

        The knowledgeable and experienced support team is readily available to address any questions or concerns that researchers may have throughout their experimental journey.

        01/03/2018

          This level of support becomes invaluable, allowing researchers to focus on their scientific objectives while receiving expert guidance alongside.

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